Recurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorInstituto Nacional de Ciência e Tecnologia - Iii-INCT-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFleury Laboratory-
Autor(es): dc.creatorDe Castro, Mateus V.-
Autor(es): dc.creatorSantos, Keity S.-
Autor(es): dc.creatorApostolico, Juliana S.-
Autor(es): dc.creatorFernandes, Edgar R.-
Autor(es): dc.creatorAlmeida, Rafael R.-
Autor(es): dc.creatorLevin, Gabriel-
Autor(es): dc.creatorMagawa, Jhosiene Y.-
Autor(es): dc.creatorNunes, João Paulo S.-
Autor(es): dc.creatorBruni, Mirian-
Autor(es): dc.creatorYamamoto, Marcio M.-
Autor(es): dc.creatorLima, Ariane C.-
Autor(es): dc.creatorSilva, Monize V. R.-
Autor(es): dc.creatorMatos, Larissa R. B.-
Autor(es): dc.creatorCoria, Vivian R.-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorScliar, Marilia O.-
Autor(es): dc.creatorKuramoto, Andreia-
Autor(es): dc.creatorBruno, Fernanda R.-
Autor(es): dc.creatorJacintho, Lucas C.-
Autor(es): dc.creatorNunes, Kelly-
Autor(es): dc.creatorWang, Jaqueline Y. T.-
Autor(es): dc.creatorCoelho, Veronica P.-
Autor(es): dc.creatorNeto, Miguel Mitne-
Autor(es): dc.creatorMaciel, Rui M. B.-
Autor(es): dc.creatorNaslavsky, Michel S.-
Autor(es): dc.creatorPassos-Bueno, Maria Rita-
Autor(es): dc.creatorBoscardin, Silvia B.-
Autor(es): dc.creatorRosa, Daniela S.-
Autor(es): dc.creatorKalil, Jorge-
Autor(es): dc.creatorZatz, Mayana-
Autor(es): dc.creatorCunha-Neto, Edecio-
Data de aceite: dc.date.accessioned2025-08-21T16:23:37Z-
Data de disponibilização: dc.date.available2025-08-21T16:23:37Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1098/rsob.210240-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231612-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231612-
Descrição: dc.descriptionRecurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases suggests that other types of immune response are involved in protection against recurrence. Here, we investigated the innate type I/III interferon (IFN) response, binding and nAb assays and T-cell responses to severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) with IFN gamma (IFNγ) enzyme-linked spot assay (ELISPOT) in three pairs of young adult monozygotic (MZ) twins with previous confirmed COVID-19, one of them presenting a severe recurrence four months after the initial infection. Twin studies have been of paramount importance to comprehend the immunogenetics of infectious diseases. Each MZ twin pair was previously exposed to SARS-CoV-2, as seen by clinical reports. The six individuals presented similar overall recovered immune responses except for the recurrence case, who presented a drastically reduced number of recognized SARS-CoV-2 T-cell epitopes on ELISPOT as compared to her twin sister and the other twin pairs. Our results suggest that the lack of a broad T-cell response to initial infection may have led to recurrence, emphasizing that an effective SARS-CoV-2-specific T-cell immune response is key for complete viral control and avoidance of clinical recurrence of COVID-19.-
Descrição: dc.descriptionHuman Genome and Stem Cell Research Center (HUG-CELL) Biosciences Institute Universidade de São Paulo, SP-
Descrição: dc.descriptionLaboratory of Immunology Heart Institute (InCor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), SP-
Descrição: dc.descriptionInstitute for Investigation in Immunology Instituto Nacional de Ciência e Tecnologia - Iii-INCT, SP-
Descrição: dc.descriptionDivision of Clinical Immunology and Allergy Department of Medicine Faculdade de Medicina da Universidade de São Paulo (FMUSP), SP-
Descrição: dc.descriptionDepartment of Microbiology Immunology and Parasitology Universidade Federal de São Paulo (UNIFESP/EPM), SP-
Descrição: dc.descriptionDepartment of Parasitology Biosciences Institute Universidade de São Paulo, SP-
Descrição: dc.descriptionSchool of Medicine Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionFleury Laboratory, SP-
Descrição: dc.descriptionSchool of Medicine Universidade Estadual Paulista (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationOpen Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectimmunity-
Palavras-chave: dc.subjectrecurrence-
Palavras-chave: dc.subjectsevere acute respiratory distress syndrome coronavirus 2-
Palavras-chave: dc.subjectT cell-
Palavras-chave: dc.subjecttwins-
Título: dc.titleRecurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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