Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorFaculdade de Medicina de São José Do Rio Preto (FAMERP)-
Autor(es): dc.contributorUniversity College London (UCL)-
Autor(es): dc.creatorCorrêa, Mab P.-
Autor(es): dc.creatorCorreia-Silva, Rebeca D.-
Autor(es): dc.creatorSasso, Gisela R. Silva-
Autor(es): dc.creatorD’Ávila, Solange C. G. P.-
Autor(es): dc.creatorGreco, Karin V.-
Autor(es): dc.creatorOliani, Sonia M.-
Autor(es): dc.creatorGil, Cristiane D.-
Data de aceite: dc.date.accessioned2025-08-21T15:58:18Z-
Data de disponibilização: dc.date.available2025-08-21T15:58:18Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10753-021-01608-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231600-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231600-
Descrição: dc.descriptionThe pathogenesis of atopic dermatitis (AD) and psoriasis (Ps) overlaps, particularly the activation of the immune response and tissue damage. Here, we evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A. Skin biopsies from AD, Ps, and control patients were evaluated using histological and immunohistochemical analyses. Six studies containing publicly available transcriptome data were individually analyzed using the GEO2R tool to detect Gal-1 and Gal-3 mRNA levels. In vitro, IL-4- or IL-17A-stimulated keratinocytes were treated with or without Gal-1 or Gal-3 to evaluate cytokine release and migration. Our findings showed different patterns of expression for Gal-1 and Gal-3 in AD and Ps skins. Densitometric analysis in skin samples showed a marked increase in the protein Gal-1 levels in Ps epidermis and in both AD and Ps dermis compared to controls. Protein and mRNA Gal-3 levels were downregulated in AD and Ps lesional skin compared with the control samples. In vitro, both galectins addition abrogated the release of IL-8 and RANTES in IL-17-stimulated keratinocytes after 24 h, whereas IL-6 release was downregulated by Gal-3 and Gal-1 in IL-4- and IL-17-stimulated cells, respectively. Administration of both galectins also increased the rate of keratinocyte migration under IL-4 or IL-17 stimulation conditions compared with untreated cells. Altogether, the immunoregulatory and migration effects of Gal-1 and Gal-3 on keratinocytes under inflammatory microenvironment make them interesting targets for future therapies in cutaneous diseases. Graphical abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Instituto de Biociências Letras E Ciências Exatas Programa de Pós-Graduação Em Biociências, SP-
Descrição: dc.descriptionDepartamento de Morfologia E Genética Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina, Rua Botucatu 740, Ed. Lemos Torres – 3º andar, SP-
Descrição: dc.descriptionFaculdade de Medicina de São José Do Rio Preto (FAMERP) Departamento de Patologia E Medicina Forense, SP-
Descrição: dc.descriptionDivision of Surgery and Interventional Science The Griffin Institute University College London (UCL)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Instituto de Biociências Letras E Ciências Exatas Programa de Pós-Graduação Em Biociências, SP-
Idioma: dc.languageen-
Relação: dc.relationInflammation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHaCaT cells-
Palavras-chave: dc.subjectIL-17A-
Palavras-chave: dc.subjectIL-4-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectskin-
Palavras-chave: dc.subjecttranscriptome-
Título: dc.titleExpression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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