Evaluation of Myrcia bella in murine osteosarcoma cells: Effect of the extract and enriched fractions of tannins and flavonoids

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFakhoury, Vanessa Svizzero-
Autor(es): dc.creatorPessoa, Adriano de Souza-
Autor(es): dc.creatorTokuhara, Cintia Kazuko-
Autor(es): dc.creatorPagnan, Ana Lígia-
Autor(es): dc.creatorOliveira, Gabriela Silva Neubern de-
Autor(es): dc.creatorLiessa, Mariana Rovis Sanches-
Autor(es): dc.creatorInacio, Kelly Karina-
Autor(es): dc.creatorMelo, Fernanda Pereira de Souza Rosa de-
Autor(es): dc.creatorDokkedal, Anne Lígia-
Autor(es): dc.creatorOliveira, Rodrigo Cardoso de-
Autor(es): dc.creatorSaldanha, Luiz Leonardo-
Data de aceite: dc.date.accessioned2025-08-21T20:39:01Z-
Data de disponibilização: dc.date.available2025-08-21T20:39:01Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2021.2018431-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231576-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231576-
Descrição: dc.descriptionMyrcia bella Cambess (Myrtaceae) is an important and common plant, native to the Brazilian Cerrado, with cytotoxicity, antimicrobial, and antidiabetic properties. Therefore, the effects of crude hydroalcoholic extract (CE) and fractions of ellagitannins (ELT) and flavonoids (FV) from Myrcia bella leaves were evaluated in a UMR-106 murine osteosarcoma cells and MC3T3 (normal cell). Cell viability and migration, production of reactive oxygen species (ROS) and matrix metalloproteinase (MMP) −2 and −9 activities were evaluated. In general, CE (80 µg/mL), ELT (160 µg/mL) and FV (64 µg/mL) reduced cell viability (p < 0.05). FV (64 µg/mL) was more effective in inhibition of cell migration, ROS production, and MMP-2 activity when compared to CE and ELT. Myrcia bella a rich source of phenolic compounds and its fraction of flavonoids have cytotoxic effects on osteosarcoma cells, preserving the viability of normal osteoblasts. Due to its antioxidant capacity, flavonoid may be a new therapeutic strategy for cancer.-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionDepartment of Biological Science São Paulo State University-
Descrição: dc.descriptionDepartment of Biological Science São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCell viability-
Palavras-chave: dc.subjectFlavonoids-
Palavras-chave: dc.subjectMedicinal plants-
Palavras-chave: dc.subjectMyrcia bella-
Palavras-chave: dc.subjectOsteosarcoma-
Título: dc.titleEvaluation of Myrcia bella in murine osteosarcoma cells: Effect of the extract and enriched fractions of tannins and flavonoids-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.