HLA-G genetic diversity and evolutive aspects in worldwide populations

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorLondon School of Hygiene and Tropical Medicine-
Autor(es): dc.contributorUniversity College London (UCL)-
Autor(es): dc.contributorUniversity of Bristol-
Autor(es): dc.contributorUniversitat Pompeu Fabra-
Autor(es): dc.contributorUnversity of Zurich-
Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorde Almeida, Bibiana S.-
Autor(es): dc.creatorMuniz, Yara C. N.-
Autor(es): dc.creatorSilva, Nayane S. B.-
Autor(es): dc.creatorPassos, Marília R. S.-
Autor(es): dc.creatorSouza, Andreia S.-
Autor(es): dc.creatorPage, Abigail E.-
Autor(es): dc.creatorDyble, Mark-
Autor(es): dc.creatorSmith, Daniel-
Autor(es): dc.creatorAguileta, Gabriela-
Autor(es): dc.creatorBertranpetit, Jaume-
Autor(es): dc.creatorMigliano, Andrea B.-
Autor(es): dc.creatorDuarte, Yeda A. O.-
Autor(es): dc.creatorScliar, Marília O.-
Autor(es): dc.creatorWang, Jaqueline-
Autor(es): dc.creatorPassos-Bueno, Maria Rita-
Autor(es): dc.creatorNaslavsky, Michel S.-
Autor(es): dc.creatorZatz, Mayana-
Autor(es): dc.creatorMendes-Junior, Celso Teixeira-
Autor(es): dc.creatorDonadi, Eduardo A.-
Data de aceite: dc.date.accessioned2025-08-21T23:47:17Z-
Data de disponibilização: dc.date.available2025-08-21T23:47:17Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-02106-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231561-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231561-
Descrição: dc.descriptionHLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes. We characterized the HLA-G genetic variability in 4640 individuals from 88 different population samples across the globe by using a state-of-the-art method to characterize polymorphisms and haplotypes from high-coverage next-generation sequencing data. We also provide insights regarding the HLA-G genetic diversity and a resource for future studies evaluating HLA-G polymorphisms in different populations and association studies. Despite the great haplotype variability, we demonstrated that: (1) most of the HLA-G polymorphisms are in introns and regulatory sequences, and these are the sites with evidence of balancing selection, (2) linkage disequilibrium is high throughout the gene, extending up to HLA-A, (3) there are few proteins frequently observed in worldwide populations, with lack of variation in residues associated with major HLA-G biological properties (dimer formation, interaction with leukocyte receptors). These observations corroborate the role of HLA-G as an immune checkpoint molecule rather than as an antigen-presenting molecule. Understanding HLA-G variability across populations is relevant for disease association and functional studies.-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDivision of Clinical Immunology Department of Medicine Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionLaboratório Multiusuário de Estudos em Biologia Centro de Ciências Biológicas Universidade Federal de Santa Catarina (UFSC)-
Descrição: dc.descriptionDepartamento de Biologia Celular Embriologia e Genética Centro de Ciências Biológicas Universidade Federal de Santa Catarina (UFSC)-
Descrição: dc.descriptionDepartment of Population Health London School of Hygiene and Tropical Medicine-
Descrição: dc.descriptionDepartament of Anthropology University College London (UCL)-
Descrição: dc.descriptionBristol Medical School (PHS) University of Bristol-
Descrição: dc.descriptionDepartment of Experimental and Health Sciences Universitat Pompeu Fabra-
Descrição: dc.descriptionDepartament of Anthropology Unversity of Zurich-
Descrição: dc.descriptionEscola de Enfermagem e Faculdade de Saúde Pública Universidade de São Paulo (USP)-
Descrição: dc.descriptionHuman Genome and Stem Cell Research Center Biosciences Institute University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Genetics and Evolutionary Biology Biosciences Institute University of São Paulo (USP)-
Descrição: dc.descriptionHospital Israelita Albert Einstein-
Descrição: dc.descriptionDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology School of Medicine São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleHLA-G genetic diversity and evolutive aspects in worldwide populations-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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