A New Curcuminoids-Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Properties

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorde Moura, Aniele-
Autor(es): dc.creatorGaglieri, Caroline-
Autor(es): dc.creatorAlarcon, Rafael Turra-
Autor(es): dc.creatorFerreira, Laura Teófilo-
Autor(es): dc.creatorVecchi, Rafael-
Autor(es): dc.creatorSanches, Mariana Liessa Rovis-
Autor(es): dc.creatorde Oliveira, Rodrigo Cardoso-
Autor(es): dc.creatorVenturini, James-
Autor(es): dc.creatorda Silva-Filho, Luiz Carlos-
Autor(es): dc.creatorJunior Caires, Flávio-
Data de aceite: dc.date.accessioned2025-08-21T18:09:49Z-
Data de disponibilização: dc.date.available2025-08-21T18:09:49Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/slct.202103359-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231546-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231546-
Descrição: dc.descriptionOver the years, several drugs have been developed deriving from plants to investigate possible therapeutic roles. Among them, curcuminoids and coumarins, which, display a wide range of biological activity against several strains. Therefore, it was synthesized a curcuminoids-coumarin derivative by a mechanochemical multicomponent reaction. By NMR and HRMS results confirmed the formation of a mixture of three curcuminoids-coumarin derivatives in the same sample. The Influence of time during the milling process was evaluated, resulting in a crystalline product in only 30 min. The LAG milling carried out with different solvents showed that the product is obtained regardless of the solvent polarity. Furthermore, the biological evaluation showed that the curcuminoids-coumarin derivative has better activity against S. aureus than curcumin and 4-hydroxycoumarin. Lastly, the cell viability study exhibited a decrease of cytotoxicity of the derivative, compared to curcumin, against NIH3T3 cells.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSchool of Sciences Chemistry Department UNESP São Paulo State University-
Descrição: dc.descriptionInstitute of Chemistry UNESP-São Paulo State University-
Descrição: dc.descriptionMedicine School Tropical Diseases and Imaging Diagnosis UNESP-São Paulo State University-
Descrição: dc.descriptionBauru School of Dentistry Department of Biological Sciences USP-University of São Paulo-
Descrição: dc.descriptionMedicine School UFMS- Mato Grosso do Sul Federal University-
Descrição: dc.descriptionSchool of Sciences Chemistry Department UNESP São Paulo State University-
Descrição: dc.descriptionInstitute of Chemistry UNESP-São Paulo State University-
Descrição: dc.descriptionMedicine School Tropical Diseases and Imaging Diagnosis UNESP-São Paulo State University-
Descrição: dc.descriptionCAPES: 024/2012 Pro-equipment-
Formato: dc.format11352-11361-
Idioma: dc.languageen-
Relação: dc.relationChemistrySelect-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiological activity-
Palavras-chave: dc.subjectCurcuminoids-
Palavras-chave: dc.subjectMechanochemistry-
Palavras-chave: dc.subjectMulticomponent reactions-
Palavras-chave: dc.subjectSustainable chemistry.-
Título: dc.titleA New Curcuminoids-Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Properties-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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