The new 2019-EULAR/ACR classification criteria specific domains at diagnosis can predict damage accrual in 670 childhood-onset systemic lupus erythematosus patients

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorHospital da Criança de Brasília Jose Alencar-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorHospital Geral de Fortaleza-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorPedro Ernesto University Hospital-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericórdia de Sao Paulo-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorHospital Menino Jesus-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.creatorPitta, Ana C-
Autor(es): dc.creatorSilva, Clovis A-
Autor(es): dc.creatorInsfrán, Carlos E-
Autor(es): dc.creatorPasoto, Sandra G-
Autor(es): dc.creatorTrindade, Vitor C-
Autor(es): dc.creatorNovak, Glaucia V-
Autor(es): dc.creatorSakamoto, Ana P-
Autor(es): dc.creatorTerreri, Maria T-
Autor(es): dc.creatorPereira, Rosa MR-
Autor(es): dc.creatorMagalhães, Claudia S-
Autor(es): dc.creatorFonseca, Adriana R-
Autor(es): dc.creatorIslabão, Aline G-
Autor(es): dc.creatorAssad, Ana PL-
Autor(es): dc.creatorBuscatti, Izabel M-
Autor(es): dc.creatorElias, Adriana M-
Autor(es): dc.creatorPiotto, Daniela P-
Autor(es): dc.creatorFerriani, Virginia P-
Autor(es): dc.creatorCarvalho, Luciana M-
Autor(es): dc.creatorRabelo Junior, Carlos N-
Autor(es): dc.creatorMarini, Roberto-
Autor(es): dc.creatorSztajnbok, Flavio R-
Autor(es): dc.creatorSacchetti, Silvana B-
Autor(es): dc.creatorBica, Blanca E-
Autor(es): dc.creatorMoraes, Ana J-
Autor(es): dc.creatorRobazzi, Teresa C-
Autor(es): dc.creatorLotufo, Simone-
Autor(es): dc.creatorCavalcanti, Andre S-
Autor(es): dc.creatorNaka, Erica N-
Autor(es): dc.creatorCarneiro-Sampaio, Magda-
Autor(es): dc.creatorBonfá, Eloisa-
Autor(es): dc.creatorAikawa, Nadia E-
Data de aceite: dc.date.accessioned2025-08-21T18:13:52Z-
Data de disponibilização: dc.date.available2025-08-21T18:13:52Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/09612033211054397-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231543-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231543-
Descrição: dc.descriptionObjective: To evaluate if the 2019-European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) criteria at diagnosis of childhood-onset systemic lupus erythematosus (cSLE) are associated with higher rates of early damage scored by Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI). Methods: This retrospective multicenter study included 670 cSLE patients with ≤5 years of disease duration. All patients fulfilled both 2019-EULAR/ACR and 1997-ACR classification criteria. Total score of 2019-EULAR/ACR criteria and each of its specific domains were assessed at diagnosis as predictors of damage accrual at the last visit, according to the presence of any organ damage (defined by SDI ≥ 1). Results: Median disease duration was 2.8 (IQR 1.8–3.8) years and 200 (29.9%) patients had at least one organ damage (SDI ≥ 1). The most frequent domains were neuropsychiatric (12%), renal (7%), and musculoskeletal (6%). There was a higher frequency of renal (58% vs 43%, p = 0.0004) and neuropsychiatric domain (21% vs 7%, p < 0.0001) of 2019-EULAR/ACR criteria in patients with damage (SDI ≥ 1) compared to those without damage (SDI = 0). Patients scoring renal or neuropsychiatric domains of the 2019-EULAR/ACR criteria at diagnosis were associated with renal damage (odds ratio 9.701, 95% confidence interval 3.773–24.941, p < 0.001) or neuropsychiatric damage (OR 9.480, 95% CI 5.481–16.399, p<0.0001) at latest visit, respectively. cSLE patients with positive anti-dsDNA at diagnosis were also associated with renal damage by the latest visit (OR 2.438, 95% CI 1.114–5.3381, p = 0.021). Constitutional, hematologic, mucocutaneous, serosal, and musculoskeletal domains and specific criteria as well as other immunologic criteria were not associated with damage accrual. Median of SLEDAI-2K was significantly higher in patients with global damage (19.5 (2–51) vs 14 (0–51), p<0.001). 2019-EULAR/ACR score >25 was associated with more overall (SDI ≥ 1) (38% vs 25%, p = 0.0002) and renal damage (11% vs 5%, p = 0.023). Conclusions: The 2019-EULAR/ACR criteria at diagnosis were associated with a higher rate of early damage in cSLE patients, especially for renal and neuropsychiatric damage. Of note, damage was particularly associated with high disease activity at diagnosis and 2019-EULAR/ACR score >25.-
Descrição: dc.descriptionPediatric Rheumatology Unit Children’s Institute Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo-
Descrição: dc.descriptionDivision of Rheumatology Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal de Sao Paulo-
Descrição: dc.descriptionPediatric Rheumatology Division Sao Paulo State University (UNESP)-
Descrição: dc.descriptionPediatric Rheumatology Unit Janeiro Federal University (IPPMG-UFRJ)-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital da Criança de Brasília Jose Alencar-
Descrição: dc.descriptionPost-graduation Program in Medical Science and Rheumatology Unit University of Brasilia-
Descrição: dc.descriptionPediatric Rheumatology Unit Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Geral de Fortaleza-
Descrição: dc.descriptionPediatric Rheumatology Unit University of Campinas (UNICAMP)-
Descrição: dc.descriptionPediatric Rheumatology Unit Pedro Ernesto University Hospital-
Descrição: dc.descriptionPediatric Rheumatology Unit Irmandade da Santa Casa de Misericórdia de Sao Paulo-
Descrição: dc.descriptionRheumatology Division - Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Pará-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Bahia-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Menino Jesus-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Pernambuco-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Mato Grosso do Sul-
Descrição: dc.descriptionPediatric Rheumatology Division Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationLupus-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2019-EULAR/ACR criteria-
Palavras-chave: dc.subjectChildhood systemic lupus erythematosus-
Palavras-chave: dc.subjectdisease damage-
Palavras-chave: dc.subjectorgan damage-
Palavras-chave: dc.subjectSLICC/ACR Damage Index-
Título: dc.titleThe new 2019-EULAR/ACR classification criteria specific domains at diagnosis can predict damage accrual in 670 childhood-onset systemic lupus erythematosus patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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