TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Vicente, Larissa G.-
Autor(es): dc.creatorMuñoz, Vitor R.-
Autor(es): dc.creatorPinto, Ana P.-
Autor(es): dc.creatorRovina, Rafael L.-
Autor(es): dc.creatorda Rocha, Alisson L.-
Autor(es): dc.creatorMarafon, Bruno B.-
Autor(es): dc.creatorTavares, Maria Eduarda de A.-
Autor(es): dc.creatorTeixeira, Giovana R.-
Autor(es): dc.creatorFerrari, Gustavo D.-
Autor(es): dc.creatorAlberici, Luciane C.-
Autor(es): dc.creatorFrantz, Fabiani G.-
Autor(es): dc.creatorSimabuco, Fernando M.-
Autor(es): dc.creatorRopelle, Eduardo R.-
Autor(es): dc.creatorde Moura, Leandro P.-
Autor(es): dc.creatorCintra, Dennys E.-
Autor(es): dc.creatorPauli, José R.-
Autor(es): dc.creatorda Silva, Adelino S.R.-
Data de aceite: dc.date.accessioned2025-08-21T22:03:01Z-
Data de disponibilização: dc.date.available2025-08-21T22:03:01Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2021.119988-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231530-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231530-
Descrição: dc.descriptionStrategies capable of attenuating TLR4 can attenuate metabolic processes such as inflammation, endoplasmic reticulum (ER) stress, and apoptosis in the body. Physical exercise has been a cornerstone in suppressing inflammation and dysmetabolic outcomes caused by TRL4 activation. Thus, the present study aimed to evaluate the effects of a chronic physical exercise protocol on the TLR4 expression and its repercussion in the inflammation, ER stress, and apoptosis pathways in mice hearts. Echocardiogram, RT-qPCR, immunoblotting, and histological techniques were used to evaluate the left ventricle of wild-type (WT) and Tlr4 knockout (TLR4 KO) mice submitted to a 4-week physical exercise protocol. Moreover, we performed a bioinformatics analysis to expand the relationship of Tlr4 mRNA in the heart with inflammation, ER stress, and apoptosis-related genes of several isogenic strains of BXD mice. The TLR4 KO mice had higher energy expenditure and heart rate in the control state but lower activation of apoptosis and ER stress pathways. The bioinformatics analysis reinforced these data. In the exercised state, the WT mice improved performance and cardiac function. However, these responses were blunted in the KO group. In conclusion, TLR4 has an essential role in the inhibition of apoptosis and ER stress pathways, as well as in the training-induced beneficial adaptations.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP)-
Descrição: dc.descriptionDepartment of Biomolecular Sciences School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo-FCFRP USP-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto Department of Clinical Toxicological and Bromatological Analysis University of São Paulo (USP)-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2017/09038-1-
Descrição: dc.descriptionFAPESP: 2020/04269-8-
Descrição: dc.descriptionCNPq: 301279/2019–5-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioinformatics-
Palavras-chave: dc.subjectKnockout model-
Palavras-chave: dc.subjectMolecular signaling pathways-
Palavras-chave: dc.subjectMorphofunctional characteristics-
Palavras-chave: dc.subjectRegular exercise-
Título: dc.titleTLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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