Effects of Fluoride on Submandibular Glands of Mice: Changes in Oxidative Biochemistry, Proteomic Profile, and Genotoxicity

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Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorEvandro Chagas Institute-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Nebraska-Lincoln-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLima, Leidiane Alencar de Oliveira-
Autor(es): dc.creatorMiranda, Giza Hellen Nonato-
Autor(es): dc.creatorAragão, Walessa Alana Bragança-
Autor(es): dc.creatorBittencourt, Leonardo Oliveira-
Autor(es): dc.creatordos Santos, Sávio Monteiro-
Autor(es): dc.creatorde Souza, Michel Platini Caldas-
Autor(es): dc.creatorNogueira, Lygia S.-
Autor(es): dc.creatorde Oliveira, Edivaldo Herculano Corrêa-
Autor(es): dc.creatorMonteiro, Marta Chagas-
Autor(es): dc.creatorDionizio, Aline-
Autor(es): dc.creatorLeite, Aline Lima-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorBuzalaf, Marília Afonso Rabelo-
Autor(es): dc.creatorLima, Rafael Rodrigues-
Data de aceite: dc.date.accessioned2025-08-21T15:30:04Z-
Data de disponibilização: dc.date.available2025-08-21T15:30:04Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-09-27-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphar.2021.715394-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231526-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231526-
Descrição: dc.descriptionAlthough fluoride (F) is well-known to prevent dental caries, changes in cell processes in different tissues have been associated with its excessive exposure. Thus, this study aimed to evaluate the effects of F exposure on biochemical, proteomic, and genotoxic parameters of submandibular glands. Twenty one old rats (n = 30) were allocated into three groups: 60 days administration of drinking water containing 10 mgF/L, 50 mgF/L, or only deionized water (control). The submandibular glands were collected for oxidative biochemistry, protein expression profile, and genotoxic potential analyses. The results showed that both F concentrations increased the levels of thiobarbituric acid–reactive substances (TBARS) and reduced glutathione (GSH) and changed the proteomic profile, mainly regarding the cytoskeleton and cellular activity. Only the exposure to 50 mgF/L induced significant changes in DNA integrity. These findings reinforce the importance of continuous monitoring of F concentration in drinking water and the need for strategies to minimize F intake from other sources to obtain maximum preventive/therapeutic effects and avoid potential adverse effects.-
Descrição: dc.descriptionLaboratory of Functional and Structural Biology Institute of Biological Sciences Federal University of Pará-
Descrição: dc.descriptionLaboratory of Clinical Immunology and Oxidative Stress Faculty of Pharmacy Institute of Health Sciences Federal University of Pará-
Descrição: dc.descriptionSection of Parasitology Evandro Chagas Institute-
Descrição: dc.descriptionLaboratory of Cell Culture and Cytogenetics Environment Section Evandro Chagas Institute-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionDepartment of Chemistry University of Nebraska-Lincoln-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectgenotoxicity-
Palavras-chave: dc.subjectproteome-
Palavras-chave: dc.subjectsubmandibular gland-
Palavras-chave: dc.subjecttoxicity-
Título: dc.titleEffects of Fluoride on Submandibular Glands of Mice: Changes in Oxidative Biochemistry, Proteomic Profile, and Genotoxicity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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