Influence of interleukin 17 A and 17 F polymorphisms in keratoconus

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorLaboratory of Immunogenetics-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital de Base of the Regional Medical Faculty Foundation (HB-FUNFARME)-
Autor(es): dc.contributorVisum Clinic-
Autor(es): dc.creatorGomes, Isabela Bronchtein-
Autor(es): dc.creatorAyo, Christiane Maria-
Autor(es): dc.creatorLopes, Alessandro Garcia-
Autor(es): dc.creatorKumano, Laurie Sayuri-
Autor(es): dc.creatorde Faria Junior, Geraldo Magela-
Autor(es): dc.creatorde Almeida, Gildásio Castello-
Autor(es): dc.creatorCastiglioni, Lilian-
Autor(es): dc.creatorde Mattos, Luiz Carlos-
Autor(es): dc.creatorBrandão, Cinara Cássia-
Data de aceite: dc.date.accessioned2025-08-21T22:26:50Z-
Data de disponibilização: dc.date.available2025-08-21T22:26:50Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11033-021-06708-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231514-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231514-
Descrição: dc.descriptionBackground: Until a few years ago, keratoconus was defined as a noninflammatory degenerative disease. However, recent studies have shown that the altered balance between inflammatory cytokines, proteases, and protease inhibitors, as well as free radicals and oxidants, have a crucial role in the pathogenesis of this disease. The aim of this study is to investigate whether interleukin 17 A G197A (rs2275913) and interleukin 17 F T7488C (rs763780) polymorphisms are associated with keratoconus in patients from a population of the northwestern region of the State of São Paulo, Brazil. Methods and Results: 35 patients and 61 controls were enrolled. Genotyping of interleukin 17 A G197A and interleukin 17 F T7488C polymorphisms was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Statistical analyses were conducted using the chi-square test, and an odds ratio with a 95% confidence interval was also calculated to evaluate the association between polymorphisms and disease. Evaluating interleukin 17 F T7488C, we found that the TT genotype is associated as a risk factor for keratoconus (P = 0.04; OR = 3.01; CI 1.11–8.14). As for evaluating interleukin 17 A G197A, the allele and genotype frequencies between patients and controls were compared and no statistically significant differences were found. Conclusions: Our data showed that the interleukin 17 F T7488C polymorphisms may exert an influence in keratoconus.-
Descrição: dc.descriptionFaculty of Medicine of São José do Rio Preto (FAMERP) Department of Molecular Biology Laboratory of Immunogenetics-
Descrição: dc.descriptionDepartment of Biology São Paulo State University “Júlio de Mesquista Filho” (UNESP)-
Descrição: dc.descriptionOphthalmology Outpatient Clinic Hospital de Base of the Regional Medical Faculty Foundation (HB-FUNFARME)-
Descrição: dc.descriptionVisum Clinic-
Descrição: dc.descriptionDepartment of Biology São Paulo State University “Júlio de Mesquista Filho” (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationMolecular Biology Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectEctasia-
Palavras-chave: dc.subjectGenetic polymorphisms-
Palavras-chave: dc.subjectIL17 genotypes-
Palavras-chave: dc.subjectInterleukins-
Palavras-chave: dc.subjectKeratoconus-
Título: dc.titleInfluence of interleukin 17 A and 17 F polymorphisms in keratoconus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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