Evaluation of hematological, biochemical and oxidative stress profile in calves under propofol anesthesia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Juiz de Fora (UFJF)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity Center of the Integrated Faculties of Ourinhos (Unifio)-
Autor(es): dc.creatorLima, Pedro Paulo Arcanjo-
Autor(es): dc.creatorNarciso, Luis Gustavo-
Autor(es): dc.creatorAlcindo, Jefferson Filgueira-
Autor(es): dc.creatorDeschk, Maurício-
Autor(es): dc.creatorCiarlini, Paulo Cesar-
Autor(es): dc.creatordos Santos, Paulo Sérgio Patto-
Autor(es): dc.creatorde Almeida, Breno Fernando Martins-
Data de aceite: dc.date.accessioned2025-08-21T19:17:05Z-
Data de disponibilização: dc.date.available2025-08-21T19:17:05Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11259-021-09826-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231501-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231501-
Descrição: dc.descriptionPropofol is a widely used drug in veterinary medicine to induce anesthesia; as well as the chosen compound for protocols of intravenous anesthesia. The present study aimed to describe the hematological, biochemical and oxidative stress alterations in calves kept under anesthesia by propofol in different dosages. In order to achieve this, eight Holstein calves were induced using propofol in a 5 mg/kg dosage and maintained under continuous propofol infusion for 60 min, having being administered 0.6 mg/kg/h or 0.8 mg/kg/h in crossover design with seven days interval. Blood samples were collected immediately before the anesthesia induction (baseline), and 30 min, 1, 2, 3, 4 and 5 h after the procedure started. Statistically relevant propofol influence was observed both in blood and biochemical parameters, with differences between dosages according to the time of infusion. The drug action over oxidative stress was also observed, causing a raise of the total antioxidant capacity (TAC) with an uric acid increase. Additionally, the increase of triglycerides, induced by the anesthesia maintenance with propofol, caused lipemia in the samples, which was capable of interfering directly in the measurements made by refractometry and spectrophotometry. It was concluded that, in spite of propofol induced alterations in blood and biochemical parameters, such alterations are subtle. In addition to that, the drug presented an antioxidative effect, which reinstates the safety of anesthesia maintenance with propofol in calves.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFaculty of Veterinary Medicine Federal University of Juiz de Fora (UFJF), Minas Gerais State-
Descrição: dc.descriptionFaculty of Veterinary Medicine of Araçatuba São Paulo State University (FMVA-UNESP), São Paulo State-
Descrição: dc.descriptionDepartment of Veterinary Medicine University Center of the Integrated Faculties of Ourinhos (Unifio), Rodovia BR 153, km 338, Bairro Água Do Cateto, SP-
Descrição: dc.descriptionFaculty of Veterinary Medicine of Araçatuba São Paulo State University (FMVA-UNESP), São Paulo State-
Descrição: dc.descriptionFAPESP: 2010/11948-7-
Descrição: dc.descriptionFAPESP: 2010/19568-9-
Formato: dc.format27-35-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Research Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectBovine-
Palavras-chave: dc.subjectContinuous infusion-
Palavras-chave: dc.subjectHemogram-
Título: dc.titleEvaluation of hematological, biochemical and oxidative stress profile in calves under propofol anesthesia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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