Obesity-induced dysbiosis exacerbates ifn-γ production and pulmonary inflammation in the mycobacterium tuberculosis infection

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPalma Albornoz, Sandra Patricia-
Autor(es): dc.creatorFraga-Silva, Thais Fernanda de Campos-
Autor(es): dc.creatorGembre, Ana Flávia-
Autor(es): dc.creatorde Oliveira, Rômulo Silva-
Autor(es): dc.creatorde Souza, Fernanda Mesquita-
Autor(es): dc.creatorRodrigues, Tamara Silva-
Autor(es): dc.creatorKettelhut, Isis Do Carmo-
Autor(es): dc.creatorManca, Camila Sanches-
Autor(es): dc.creatorJordao, Alceu Afonso-
Autor(es): dc.creatorRamalho, Leandra Naira Zambelli-
Autor(es): dc.creatorRibolla, Paulo Eduardo Martins-
Autor(es): dc.creatorCarlos, Daniela-
Autor(es): dc.creatorBonato, Vânia Luiza Deperon-
Data de aceite: dc.date.accessioned2025-08-21T22:19:48Z-
Data de disponibilização: dc.date.available2025-08-21T22:19:48Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells10071732-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231500-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231500-
Descrição: dc.descriptionThe microbiota of the gut–lung axis affects local and far-reaching immune responses and might also trigger chronic and inflammatory diseases. We hypothesized that gut dysbiosis induced by obesity, which coexists in countries with a high tuberculosis burden, aggravates the host susceptibility and the pulmonary damage tolerance. To assess our hypothesis, we used a model of high-fat diet (HFD)-induced obesity, followed by infection of C57BL/6 mice with Mycobacterium tuberculosis. We showed that obesity increased the susceptibility, the pulmonary inflammation and IFN-γ levels in M. tuberculosis-infected mice. During the comorbidity obesity and tuberculosis, there is an increase of Bacteroidetes and Firmicutes in the lungs, and an increase of Firmicutes and butyrate in the feces. Depletion of gut microbiota by antibiotic treatment in the obese infected mice reduced the frequencies of CD4+ IFN-γ+ IL-17− cells and IFN-γ levels in the lungs, associated with an increase of Lactobacillus. Our findings reinforce the role of the gut–lung axis in chronic infections and suggest that the gut microbiota modulation may be a potential host-directed therapy as an adjuvant to treat TB in the context of IFN-γ-mediated immunopathology.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBasic and Applied Immunology Program Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Health Sciences Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionBiotechnology Institute Sao Paulo State University-
Descrição: dc.descriptionBiotechnology Institute Sao Paulo State University-
Descrição: dc.descriptionFAPESP: 2015/00774-1-
Descrição: dc.descriptionFAPESP: 2017/21629-5-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGut–lung axis-
Palavras-chave: dc.subjectMicrobiota-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectTuberculosis-
Título: dc.titleObesity-induced dysbiosis exacerbates ifn-γ production and pulmonary inflammation in the mycobacterium tuberculosis infection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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