The Fibrosis-Targeted Collagen/Integrins Gene Profile Predicts Risk of Metastasis in Pulmonary Neuroendocrine Neoplasms

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPrieto, Tabatha Gutierrez-
Autor(es): dc.creatorMachado-Rugolo, Juliana-
Autor(es): dc.creatorBaldavira, Camila Machado-
Autor(es): dc.creatorVelosa, Ana Paula Pereira-
Autor(es): dc.creatorTeodoro, Walcy Rosolia-
Autor(es): dc.creatorSaber, Alexandre Muxfeldt Ab´-
Autor(es): dc.creatorCapelozzi, Vera Luiza-
Data de aceite: dc.date.accessioned2025-08-21T20:20:18Z-
Data de disponibilização: dc.date.available2025-08-21T20:20:18Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-11-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fonc.2021.706141-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231498-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231498-
Descrição: dc.descriptionRecently, collagen/integrin genes have shown promise as predictors of metastasis mainly in non-small cell lung cancer and breast cancer. However, it is unknown if these gene expression profiling differ in metastatic potential of pulmonary neuroendocrine neoplasms (PNENs). In this study, we sought to identify differentially expressed collagen/integrin genes in PNENs in order to understand the molecular mechanisms underlying the development of stroma-associated fibrosis for invasion and metastasis. We compared collagen/integrin gene expression profiling between PNE tumors (PNETs) and PNE carcinomas (PNECs) using a two-stage design. First, we used PCR Array System for 84 ECM-related genes, and among them, we found COL1A2, COL3A1, COL5A2, ITGA5, ITGAV, and ITGB1 functionally involved in the formation of the stroma-associated fibrosis among PNENs histological subtypes. Second, we examined the clinical association between the six collagen/integrin genes in tumor tissues from 24 patients with surgically excised PNENs. However, the pathological exam of their resected tissues demonstrated that 10 developed lymph node metastasis and 7 distant metastasis. We demonstrated and validated up regulation of the six fibrogenic genes in PNECs and down regulation in PNETs that were significantly associated with metastasis-free and overall survival (P<0.05). Our study implicates up regulation of fibrogenic genes as a critical molecular event leading to lymph node and distant metastasis in PNENs.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Genomics and Histomorphometry Department of Pathology University of São Paulo Medical School (USP)-
Descrição: dc.descriptionHealth Technology Assessment Center (NATS) Clinical Hospital (HCFMB) Medical School of São Paulo State University (UNESP)-
Descrição: dc.descriptionRheumatology Division of the Clinical Hospital University of São Paulo Medical School (USP)-
Descrição: dc.descriptionHealth Technology Assessment Center (NATS) Clinical Hospital (HCFMB) Medical School of São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/20403-6-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcollagens-
Palavras-chave: dc.subjectextracellular matrix-
Palavras-chave: dc.subjectintegrins-
Palavras-chave: dc.subjectmetastasis-
Palavras-chave: dc.subjectpulmonary neuroendocrine neoplasms-
Palavras-chave: dc.subjectsurgical resection-
Título: dc.titleThe Fibrosis-Targeted Collagen/Integrins Gene Profile Predicts Risk of Metastasis in Pulmonary Neuroendocrine Neoplasms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.