Toxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorGoiano Federal Institute – Urata Campus-
Autor(es): dc.contributorFederal University of Ceara-
Autor(es): dc.contributorBrazil University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorNord University-
Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorAraújo, Amanda P.C.-
Autor(es): dc.creatorGuimarães, Abraão T.B.-
Autor(es): dc.creatorVeras, Flávio P.-
Autor(es): dc.creatorBraz, Helyson L.B.-
Autor(es): dc.creatorde Pontes, Letícia G.-
Autor(es): dc.creatorJorge, Roberta J.B.-
Autor(es): dc.creatorBelo, Marco A.A.-
Autor(es): dc.creatorFernandes, Bianca H.V.-
Autor(es): dc.creatorNóbrega, Rafael H.-
Autor(es): dc.creatorGaldino, Giovane-
Autor(es): dc.creatorCondino-Neto, Antônio-
Autor(es): dc.creatorGalindo-Villegas, Jorge-
Autor(es): dc.creatorMachado-Santelli, Glaucia M.-
Autor(es): dc.creatorSanches, Paulo R.S.-
Autor(es): dc.creatorRezende, Rafael M.-
Autor(es): dc.creatorCilli, Eduardo M.-
Autor(es): dc.creatorMalafaia, Guilherme-
Data de aceite: dc.date.accessioned2025-08-21T15:29:38Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:38Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jhazmat.2021.126463-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231472-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231472-
Descrição: dc.descriptionThe Spike protein (S protein) is a critical component in the infection of the new coronavirus (SARS-CoV-2). The objective of this work was to evaluate whether peptides from S protein could cause negative impact in the aquatic animals. The aquatic toxicity of SARS-CoV-2 Spike protein peptides derivatives has been evaluated in tadpoles (n = 50 tadpoles/5 replicates of 10 animals) from species Physalaemus cuvieri (Leptodactylidae). After synthesis, purification, and characterization of peptides (PSDP2001, PSDP2002, PSDP2003) an aquatic contamination has been simulated with these peptides during 24 h of exposure in two concentrations (100 and 500 ng/mL). The control group (“C”) was composed of tadpoles kept in polyethylene containers containing de-chlorinated water. Oxidative stress, antioxidant biomarkers and AChE activity were assessed. In both concentrations, PSPD2002 and PSPD2003 increased catalase and superoxide dismutase antioxidants enzymes activities, as well as oxidative stress (nitrite levels, hydrogen peroxide and reactive oxygen species). All three peptides also increased acetylcholinesterase activity in the highest concentration. These peptides showed molecular interactions in silico with acetylcholinesterase and antioxidant enzymes. Aquatic particle contamination of SARS-CoV-2 has cholinesterasic effect in P. cuvieri tadpoles. These findings indicate that the COVID-19 can constitute environmental impact or biological damage potential.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biomedical Sciences University of Sao Paulo-
Descrição: dc.descriptionPost-graduation Program in Biotechnology and Biodiversity Goiano Federal Institution and Federal University of Goiás-
Descrição: dc.descriptionBiological Research Laboratory Post-graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute – Urata Campus-
Descrição: dc.descriptionCenter of Research in Inflammatory Diseases Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionPostgraduate Program in Morphological Science Department of Morphology School of Medicine Federal University of Ceara, Delmiro de Farias St.-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of Sao Paulo-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology School of Medicine Federal University of Ceara, Coronel Nunes de Melo St., 1127-
Descrição: dc.descriptionDrug Research and Development Center Federal University of Ceara, Coronel Nunes de Melo St., 1000-
Descrição: dc.descriptionLaboratory of Animal Pharmacology and Toxicology Brazil University-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratório de Controle Genético e Sanitário Diretoria Técnica de Apoio ao Ensino e Pesquisa Faculdade de Medicina da Universidade de São Paulo-
Descrição: dc.descriptionReproductive and Molecular Biology Group Institute of Biosciences São Paulo State University-
Descrição: dc.descriptionInstitute of Motricity Sciences Federal University of Alfenas-
Descrição: dc.descriptionFaculty of Biosciences and Aquaculture Nord University-
Descrição: dc.descriptionDepartment of Cell Biology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionBrigham and Women's Hospital Harvard Medical School, 75 Francis St-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionReproductive and Molecular Biology Group Institute of Biosciences São Paulo State University-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 307743/2018-7-
Descrição: dc.descriptionCNPq: 426531/2018-3-
Descrição: dc.descriptionFAPESP: FAPESP 2020/05761-3-
Idioma: dc.languageen-
Relação: dc.relationJournal of Hazardous Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcetylcholinesterase-
Palavras-chave: dc.subjectAmphibians-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSARS-Cov-2-
Título: dc.titleToxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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