Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMax Planck Institute of Psychiatry-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorBehavioural Neuroscience Institute (INeC)-
Autor(es): dc.contributorBoehringer Ingelheim Pharmaceuticals Die Gesellschaft mit Beschränkter Haftung & Compagnie Kommanditgesellschaft-
Autor(es): dc.creatorSoares, Victor P.M.N.-
Autor(es): dc.creatorde Andrade, Telma G.C.S.-
Autor(es): dc.creatorCanteras, Newton S.-
Autor(es): dc.creatorCoimbra, Norberto C.-
Autor(es): dc.creatorWotjak, Carsten T.-
Autor(es): dc.creatorAlmada, Rafael C.-
Data de aceite: dc.date.accessioned2025-08-21T21:32:17Z-
Data de disponibilização: dc.date.available2025-08-21T21:32:17Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2021.06.006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231471-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231471-
Descrição: dc.descriptionThe ability to distinguish between threatening (repulsors), neutral and appetitive stimuli (attractors) stimuli is essential for survival. The orexinergic neurons of hypothalamus send projections to the limbic structures, such as different subregions of the medial prefrontal cortex (mPFC), suggesting that the orexinergic mechanism in the prelimbic cortex (PL) is involved in the processing of fear and anxiety. We investigated the role of orexin receptors type 1 (OX1R) and type 2 (OX2R) in the PL in such processes upon confrontation with an erratically moving robo-beetle in mice. The selective blockade of OX1R and OX2R in the PL with SB 334867 (3, 30, 300 nM) and TCS OX2 29 (3, 30, 300 nM), respectively, did not affect general exploratory behavior or reactive fear such as avoidance, jumping or freezing, but significantly enhances tolerance and approach behavior at the highest dose of each antagonist tested (300 nM). We interpret these findings as evidence for an altered cognitive appraisal of the potential threatening stimulus. Consequently, the orexin system seems to bias the perception of stimuli towards danger or threat via OX1R and OX2R in the PL.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Sciences Humanities and Languages of the São Paulo State University (UNESP)-
Descrição: dc.descriptionNeuronal Plasticity Research Group Max Planck Institute of Psychiatry-
Descrição: dc.descriptionDepartment of Pharmacology Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP)-
Descrição: dc.descriptionDepartment of Anatomy Biomedical Sciences Institute of the University of São Paulo (ICB-USP)-
Descrição: dc.descriptionBehavioural Neuroscience Institute (INeC)-
Descrição: dc.descriptionNAP-USP-Neurobiology of Emotions Research Centre (NuPNE) Ribeirão Preto Medical School of the University of São Paulo-
Descrição: dc.descriptionCentral Nervous System Diseases Research Boehringer Ingelheim Pharmaceuticals Die Gesellschaft mit Beschränkter Haftung & Compagnie Kommanditgesellschaft-
Descrição: dc.descriptionDepartment of Biological Sciences School of Sciences Humanities and Languages of the São Paulo State University (UNESP)-
Formato: dc.format158-167-
Idioma: dc.languageen-
Relação: dc.relationNeuroscience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanxiety-
Palavras-chave: dc.subjectbeetle mania task-
Palavras-chave: dc.subjectcognitive judgment bias-
Palavras-chave: dc.subjectfear-
Palavras-chave: dc.subjectmedial prefrontal cortex-
Palavras-chave: dc.subjectorexin receptors-
Título: dc.titleOrexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.