Association between endothelial nitric oxide synthase and the renin-angiotensin-aldosterone system polymorphisms, blood pressure and training status in normotensive/pre-hypertension and hypertensive older adults: a pilot study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Minas Gerais Federal-
Autor(es): dc.creatorSilva, Roberta Fernanda da-
Autor(es): dc.creatorLacchini, Riccardo-
Autor(es): dc.creatorPinheiro, Lucas Cezar-
Autor(es): dc.creatorFerezin, Letícia Perticarrara-
Autor(es): dc.creatorTanus-Santos, José Eduardo-
Autor(es): dc.creatorLuizon, Marcelo Rizzatti-
Autor(es): dc.creatorDionísio, Thiago José-
Autor(es): dc.creatorSantos, Carlos Ferreira-
Autor(es): dc.creatorReia, Thaís Amanda-
Autor(es): dc.creatorJacomini, André Mourão-
Autor(es): dc.creatorMoreno, Ana Maria Guilmo-
Autor(es): dc.creatorZago, Anderson Saranz-
Data de aceite: dc.date.accessioned2025-08-21T23:17:10Z-
Data de disponibilização: dc.date.available2025-08-21T23:17:10Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/10641963.2021.1937202-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231467-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231467-
Descrição: dc.descriptionIntroduction:Variations in blood pressure (BP) are, in part, genetically determined and some polymorphisms of renin-angiotensin- aldosterone system (RAAS) and synthase of endothelial nitric oxide (eNOS) have been related to hypertension (HT). Conversely, physical exercise is considered a non-pharmacological tool for HT control, treatment, and prevention. Objective: The purpose of this study is to investigate the relationship between eNOS and RAAS polymorphisms, their epistatic interaction, and the respective humoral factors in the BP control in normotensive/pre-hypertension and hypertensive older adults and how this relationship can be modulated by training status (TS) level. Methods:A total of 155 older adults (66.94 ± 6.83 years old) performed the following evaluations: AAHPERD battery test to determine the general functional fitness index (GFFI), systolic and diastolic blood pressure (SBP and DBP), blood collection for DNA extraction, analysis of eNOS gene polymorphisms rs2070744; rs61722009 and rs1799983 and RAAS polymorphisms rs699; rs1799752 and rs5186, and quantification of ACE activity (Fluorimetric Assay) and nitrite concentration (Chemiluminescence Method). Results and Conclusion:Good TS level appears to exert greater influence on SBP for G2 and G3 (G1: 125.79 ± 14.03/ G2: 119.91 ± 11.72/G3: 119.71 ± 10.85) and on NO2 for G3 (G1: 0.42 ± 0.25/ G2: 0.54 ± 0.45/ G3: 0.71 ± 0.52). No associations were observed between eNOS and RAAS polymorphisms, but the epistasis was identified between eNOS polymorphism, rs2070744, and RAAS polymorphism, rs699, revealing a statistically significant interaction (p = .0235) with training score of 0.63, a training test accuracy of 0.61 and a cross-validation consistency of 10/10. This result suggests an increased risk of hypertension.-
Descrição: dc.descriptionDepartment of Physical Education Post-Graduate Program in Movement Sciences School of Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Psychiatric Nursing and Human Sciences University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Genetics Faculty of Medicine of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Pharmacology Faculty of Medicine of Ribeirão University of São Paulo (USP)-
Descrição: dc.descriptionInstitute of Biological Sciences Department of Genetics Ecology and Evolution University of Minas Gerais Federal-
Descrição: dc.descriptionDepartment of Pharmacology Bauru School of Dentistry University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Physical Education Center for Noncommunicable Diseases Aging and Exercise Studies (CEDEE) School of Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Physical Education Post-Graduate Program in Movement Sciences School of Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Physical Education Center for Noncommunicable Diseases Aging and Exercise Studies (CEDEE) School of Sciences Sao Paulo State University (Unesp)-
Formato: dc.format661-670-
Idioma: dc.languageen-
Relação: dc.relationClinical and Experimental Hypertension-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectgenetics-
Palavras-chave: dc.subjectheredity-
Palavras-chave: dc.subjecthypertension-
Título: dc.titleAssociation between endothelial nitric oxide synthase and the renin-angiotensin-aldosterone system polymorphisms, blood pressure and training status in normotensive/pre-hypertension and hypertensive older adults: a pilot study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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