Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFAIT-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorINCLIVA-
Autor(es): dc.creatorPagan, Luana U.-
Autor(es): dc.creatorGomes, Mariana J.-
Autor(es): dc.creatorDamatto, Ricardo L.-
Autor(es): dc.creatorLima, Aline R. R.-
Autor(es): dc.creatorCezar, Marcelo D. M.-
Autor(es): dc.creatorDamatto, Felipe C.-
Autor(es): dc.creatorReyes, David R. A.-
Autor(es): dc.creatorCampos, Dijon H. S.-
Autor(es): dc.creatorCaldonazo, Tulio M. M.-
Autor(es): dc.creatorPolegato, Bertha F.-
Autor(es): dc.creatorFernandes, Denise C.-
Autor(es): dc.creatorLaurindo, Francisco R.-
Autor(es): dc.creatorFernandes, Ana A. H.-
Autor(es): dc.creatorLloret, Ana-
Autor(es): dc.creatorCicogna, Antonio C.-
Autor(es): dc.creatorOkoshi, Marina P.-
Autor(es): dc.creatorOkoshi, Katashi-
Data de aceite: dc.date.accessioned2025-08-21T19:14:25Z-
Data de disponibilização: dc.date.available2025-08-21T19:14:25Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-06-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2021.675778-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231460-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231460-
Descrição: dc.descriptionAim: To evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-κB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development. Methods: We studied four experimental groups: normotensive Wistar rats (W, n = 27), trained W (W-EX, n = 31), SHR (n = 27), and exercised SHR (SHR-EX, n = 32). At 13 months old, the exercise groups underwent treadmill exercise 5 days a week for 4 months. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Antioxidant enzyme activity and energy metabolism were assessed by spectrophotometry. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was analyzed by lucigenin reduction and protein expression by Western blot. Statistical analyzes: ANOVA and Tukey or Kruskal–Wallis and Dunn tests. Results: SHR-EX had a lower frequency of heart failure features than SHR. Myocardial function and antioxidant enzyme activity were better in SHR-EX than SHR. Lipid hydroperoxide concentration, and phosphorylated JNK and total IkB protein expression were higher in hypertensive than control groups. Malondialdehyde, NADPH oxidase activity, total JNK, phosphorylated p38, phosphorylated and total p65 NF-κB, and phosphorylated IkB did not differ between groups. Protein expression from total p38, and total and phosphorylated ERK were higher in SHR than W. Lactate dehydrogenase and phosphorylated ERK were lower and citrate synthase and β-hydroxyacyldehydrogenase were higher in SHR-EX than SHR. Conclusion: Exercise improves physical capacity, myocardial function, and antioxidant enzyme activity; reduces the frequency of heart failure features and ERK phosphorylation; and normalizes energy metabolism in SHR.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionBotucatu Medical School UNESP Sao Paulo State University-
Descrição: dc.descriptionItapeva Social and Agrarian Sciences College FAIT-
Descrição: dc.descriptionDepartment of Cardiopneumology Medical School University of Sao Paulo (USP)-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFreshage Research Group Department of Physiology University of Valencia CIBERFES INCLIVA-
Descrição: dc.descriptionBotucatu Medical School UNESP Sao Paulo State University-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectheart-
Palavras-chave: dc.subjecthypertension-
Palavras-chave: dc.subjectmyocardium function-
Palavras-chave: dc.subjectphysical exercise-
Palavras-chave: dc.subjectspontaneously hypertensive rats-
Título: dc.titleAerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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