Expression patterns of peroxiredoxin genes in bronchial epithelial cells exposed to diesel exhaust particles

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorTraining and Development-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSeriani, Robson-
Autor(es): dc.creatorPaula, Carla Peres de-
Autor(es): dc.creatorCunha, Anderson Ferreira da-
Autor(es): dc.creatorOliveira, Marcos Antonio de-
Autor(es): dc.creatorKrempel, Paloma Gava-
Autor(es): dc.creatorFrias, Daniela Perroni-
Autor(es): dc.creatorNegri, Elnara Marcia-
Autor(es): dc.creatorMauad, Thais-
Autor(es): dc.creatorMacchione, Mariangela-
Data de aceite: dc.date.accessioned2025-08-21T18:55:30Z-
Data de disponibilização: dc.date.available2025-08-21T18:55:30Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.yexmp.2021.104641-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231456-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231456-
Descrição: dc.descriptionSeveral mechanisms have been suggested to explain the adverse effects of air pollutants on airway cells. One such explanation is the presence of high concentrations of oxidants and pro-oxidants in environmental pollutants. All animal and plant cells have developed several mechanisms to prevent damage by oxidative molecules. Among these, the peroxiredoxins (PRDXs) are of interest due to a high reactivity with reactive oxygen species (ROS) through the functioning of the thioredoxin/thioredoxin reductase system. This study aimed to verify the gene expression patterns of the PRDX family in bronchial epithelial airway cells (BEAS-2B) cells exposed to diesel exhaust particles (DEPs) at a concentration of 15 μg/mL for 1 or 2 h because this it is a major component of particulate matter in the atmosphere. There was a significant decrease in mRNA fold changes of PRDX2 (0.43 ± 0.34; *p = 0.0220), PRDX5 (0.43 ± 0.34; *p = 0.0220), and PRDX6 (0.33 ± 0.25; *p = 0.0069) after 1 h of exposure to DEPs. The reduction in mRNA levels may consequently lead to a decrease in the levels of PRDX proteins, increasing oxidative stress in bronchial epithelial cells BEAS-2B and thus, negatively affecting cellular functions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Experimental Air Pollution (LIM05) Department of Pathology School of Medicine University of São Paulo, FMUSP- Av. Dr. Arnaldo 455, 1°floor, room 1150-
Descrição: dc.descriptionPROSCED – Consulting Training and Development, Rua Alto Belo, 742, room 01-
Descrição: dc.descriptionGenetic and Evolution Department Federal University of São Carlos, UFSCar- Av. Washington Luiz Km 235-
Descrição: dc.descriptionBiosciences Institute Coastal Campus São Paulo State University Structural and Functional Molecular Biology, UNESP- Praça Infante Dom Henrique s/n°-
Descrição: dc.descriptionLaboratory for Investigations in Ophthalmology (LIM-33) University of São Paulo Medical School São Paulo, FMUSP - Dr. Arnaldo 455, 5°andar, Cerqueira César-
Descrição: dc.descriptionBiosciences Institute Coastal Campus São Paulo State University Structural and Functional Molecular Biology, UNESP- Praça Infante Dom Henrique s/n°-
Descrição: dc.descriptionFAPESP: 2011/50334-7-
Idioma: dc.languageen-
Relação: dc.relationExperimental and Molecular Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAir pollution-
Palavras-chave: dc.subjectBEAS-2B-
Palavras-chave: dc.subjectDiesel exhaust particles-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPeroxiredoxins-
Título: dc.titleExpression patterns of peroxiredoxin genes in bronchial epithelial cells exposed to diesel exhaust particles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.