Thiazole derivatives act on virulence factors of Cryptococcus spp

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Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniv Estadual de São Paulo-
Autor(es): dc.creatorDe Sa, Nívea Pereira-
Autor(es): dc.creatorDe Barros, Patrícia Pimentel-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorVaz, Jéssica Aparecida-
Autor(es): dc.creatorDe Oliveira, Renata Barbosa-
Autor(es): dc.creatorRosa, Carlos Augusto-
Autor(es): dc.creatorSantos, Daniel Assis-
Autor(es): dc.creatorJohann, Susana-
Data de aceite: dc.date.accessioned2025-08-21T20:44:29Z-
Data de disponibilização: dc.date.available2025-08-21T20:44:29Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/mmy/myx158-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231427-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231427-
Descrição: dc.descriptionCryptococcosis is an opportunistic or primary fungal infection considered to be the most prevalent fatal fungal disease worldwide. Owing to the limited number of available drugs, it is necessary to search for novel antifungal compounds. In the present work, we assessed the antifungal efficacy of three thiazole derivatives (1, 2, and 3). We conducted in vitro and in vivo assays to investigate their effects on important virulence factors, such as capsule and biofilm formation. In addition, the phagocytosis index of murine macrophages exposed to compounds 1, 2, and 3 and the in vivo efficacy of 1, 2, and 3 in Galleria mellonella infected with Cryptococcus spp. were evaluated. All compounds exhibited antifungal activity against biofilms and demonstrated a reduction in biofilm metabolic activity by 43-50% for C. gattii and 26-42% for C. neoformans. Thiazole compounds promoted significant changes in the capsule thickness of C. gattii compared to that of C. neoformans. Further examination of these compounds suggests that they can improve the phagocytosis process of peritoneal murine macrophages in vitro, causing an increase in the phagocytosis rate. Survival percentage was examined in the invertebrate model Galleria mellonella larvae, and only compound 3 could increase the survival at doses of 5 mg/kg after infection with C. gattii (P= .0001) and C. neoformans (P= .0007), similar to fluconazole at 10 mg/kg. The results demonstrated that thiazole compounds, mainly compound 3, have potential to be used for future studies in the search for new therapeutics for cryptococcosis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biological Sciences Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, PO Box 486-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Univ Estadual de São Paulo, São José dos Campos-
Descrição: dc.descriptionDepartment of Pharmaceutical Products Faculdade de Farmácia Universidade Federal de Minas Gerais-
Formato: dc.format84-91-
Idioma: dc.languageen-
Relação: dc.relationMedical Mycology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal-
Palavras-chave: dc.subjectCryptococcus-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectThiazole-
Palavras-chave: dc.subjectVirulence factor-
Título: dc.titleThiazole derivatives act on virulence factors of Cryptococcus spp-
Tipo de arquivo: dc.typelivro digital-
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