Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse

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Autor(es): dc.contributorUniversità degli Studi di Napoli Federico II-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Gothenburg-
Autor(es): dc.contributorStazione Zoologica Anton Dohrn-
Autor(es): dc.creatorCredendino, Sara Carmela-
Autor(es): dc.creatorLewin, Nicole-
Autor(es): dc.creatorDe Oliveira, Miriane-
Autor(es): dc.creatorBasu, Swaraj-
Autor(es): dc.creatorD'Andrea, Barbara-
Autor(es): dc.creatorAmendola, Elena-
Autor(es): dc.creatorDi Guida, Luigi-
Autor(es): dc.creatorNardone, Antonio-
Autor(es): dc.creatorSanges, Remo-
Autor(es): dc.creatorDe Felice, Mario-
Autor(es): dc.creatorDe Vita, Gabriella-
Data de aceite: dc.date.accessioned2025-08-21T21:55:11Z-
Data de disponibilização: dc.date.available2025-08-21T21:55:11Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2017-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2017/9769171-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231409-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231409-
Descrição: dc.descriptionlncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. Due to its genomic localization antisense to the protein-encoding Klhl14 gene, we named it Klhl14-AS. In this paper, we highlight that mouse Klhl14-AS produces at least five splicing variants, some of which have not been previously described. Klhl14-AS is expressed with a peculiar pattern, characterized by diverse relative abundance of its isoforms in different mouse tissues. We examine the whole expression level of Klhl14-AS in a panel of adult mouse tissues, showing that it is expressed in the thyroid, lung, kidney, testis, ovary, brain, and spleen, although at different levels. In situ hybridization analysis reveals that, in the context of each organ, Klhl14-AS shows a cell type-specific expression. Interestingly, databases report a similar expression profile for human Klhl14-AS. Our observations suggest that this lncRNA could play cell type-specific roles in several organs and pave the way for functional characterization of this gene in appropriate biological contexts.-
Descrição: dc.descriptionEuropean Commission-
Descrição: dc.descriptionDipartimento di Medicina Molecolare e Biotecnologie Mediche Università degli Studi di Napoli Federico II, Via S. Pansini 5-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu School of Medicine University of São Paulo State-
Descrição: dc.descriptionDepartment of Medical Biochemistry and Cell Biology Institute of Biomedicine Sahlgrenska Academy University of Gothenburg-
Descrição: dc.descriptionDipartimento di Sanità Pubblica Università degli Studi di Napoli Federico II, Via S. Pansini 5-
Descrição: dc.descriptionBiology and Evolution of Marine Organisms Stazione Zoologica Anton Dohrn, Villa Comunale 1-
Descrição: dc.descriptionEuropean Commission: RNA-REGULOMICS 318981-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Genomics-
???dc.source???: dc.sourceScopus-
Título: dc.titleTissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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