Nop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPrieto, Marcela B.-
Autor(es): dc.creatorGeorg, Raphaela C.-
Autor(es): dc.creatorGonzales-Zubiate, Fernando A.-
Autor(es): dc.creatorLuz, Juliana S.-
Autor(es): dc.creatorOliveira, Carla C.-
Data de aceite: dc.date.accessioned2025-08-21T23:04:46Z-
Data de disponibilização: dc.date.available2025-08-21T23:04:46Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2015-03-18-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12867-015-0037-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231350-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231350-
Descrição: dc.descriptionBackground: Box C/D snoRNPs are responsible for rRNA methylation and processing, and are formed by snoRNAs and four conserved proteins, Nop1, Nop56, Nop58 and Snu13. The snoRNP assembly is a stepwise process, involving other protein complexes, among which the R2TP and Hsp90 chaperone. Nop17, also known as Pih1, has been shown to be a constituent of the R2TP (Rvb1, Rvb2, Tah1, Pih1) and to participate in box C/D snoRNP assembly by its interaction with Nop58. The molecular function of Nop17, however, has not yet been described. Results: To shed light on the role played by Nop17 in the maturation of snoRNP, here we analyzed the interactions domains of Nop58 - Nop17 - Tah1 and the importance of ATP to the interaction between Nop17 and the ATPase Rvb1/2. Conclusions: Based on the results shown here, we propose a model for the assembly of box C/D snoRNP, according to which R2TP complex is important for reducing the affinity of Nop58 for snoRNA, and for the binding of the other snoRNP subunits.-
Descrição: dc.descriptionInstitute of Chemistry, University of São Paulo, Department of Biochemistry, Av. Prof. Lineu Prestes 748-
Descrição: dc.descriptionInstitute of Biological Sciences, Federal University of Goiás, Department of Biochemistry and Molecular Biology-
Descrição: dc.descriptionSão Paulo State University, Department of Biological Sciences, School of Pharmacy-
Descrição: dc.descriptionSão Paulo State University, Department of Biological Sciences, School of Pharmacy-
Idioma: dc.languageen-
Relação: dc.relationBMC Molecular Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbox C/D snoRNP assembly-
Palavras-chave: dc.subjectNop17-
Palavras-chave: dc.subjectR2TP complex-
Título: dc.titleNop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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