Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorCriciúma, Santa Catarina-
Autor(es): dc.creatorPereira, Bruno Cesar-
Autor(es): dc.creatorPauli, José Rodrigo-
Autor(es): dc.creatorAntunes, Lusânia Maria Greggi-
Autor(es): dc.creatorDe Freitas, Ellen Cristini-
Autor(es): dc.creatorDe Almeida, Mara Ribeiro-
Autor(es): dc.creatorDe Paula Venâncio, Vinícius-
Autor(es): dc.creatorRopelle, Eduardo Rochete-
Autor(es): dc.creatorDe Souza, Claudio Teodoro-
Autor(es): dc.creatorCintra, Dennys Esper-
Autor(es): dc.creatorPapoti, Marcelo-
Autor(es): dc.creatorDa Silva, Adelino Sanchez Ramos-
Data de aceite: dc.date.accessioned2025-08-21T17:42:57Z-
Data de disponibilização: dc.date.available2025-08-21T17:42:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2013-10-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/1472-6793-13-11-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231305-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231305-
Descrição: dc.descriptionBackground: The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. Although some studies on chronic and acute effects of exercise on DNA damage measured by the comet assay have been performed, it is unknown if an aerobic training protocol with intensity, volume, and load clearly defined will improve performance without leading to peripheral blood cell DNA damage. In addition, the effects of overtraining on DNA damage are unknown. Therefore, this study aimed to examine the effects of aerobic training and overtraining on DNA damage in peripheral blood and skeletal muscle cells in Swiss mice. To examine possible changes in these parameters with oxidative stress, we measured reduced glutathione (GSH) levels in total blood, and GSH levels and lipid peroxidation in muscle samples. Results: Performance evaluations (i.e., incremental load and exhaustive tests) showed significant intra and inter-group differences. The overtrained (OTR) group showed a significant increase in the percentage of DNA in the tail compared with the control (C) and trained (TR) groups. GSH levels were significantly lower in the OTR group than in the C and TR groups. The OTR group had significantly higher lipid peroxidation levels compared with the C and TR groups. Conclusions: Aerobic and anaerobic performance parameters can be improved in training at maximal lactate steady state during 8 weeks without leading to DNA damage in peripheral blood and skeletal muscle cells or to oxidative stress in skeletal muscle cells. However, overtraining induced by downhill running training sessions is associated with DNA damage in peripheral blood and skeletal muscle cells, and with oxidative stress in skeletal muscle cells and total blood. © 2013 Pereira et al.; licensee BioMed Central Ltd.-
Descrição: dc.descriptionUniversidade de São Paulo (USP) Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP), Ribeirão Preto, São Paulo-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Curso de Pós-graduação em Ciências da Motricidade Humana, Rio-Claro, São Paulo-
Descrição: dc.descriptionUniversidade de São Paulo (USP) Faculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Análises Clínicas Toxicológicas e Bromatológicas, Ribeirão Preto, São Paulo-
Descrição: dc.descriptionUniversidade Estadual de Campinas (UNICAMP) Faculdade de Ciencias Aplicadas, Curso de Pos-graduacao em Nutricao, Esporte e Metabolismo, Limeira, São Paulo-
Descrição: dc.descriptionUniversidade Do Extremo sul Catarinense Laboratório de Bioquímica e Fisiologia Criciúma, Santa Catarina-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Curso de Pós-graduação em Ciências da Motricidade Humana, Rio-Claro, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationBMC Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAerobic training-
Palavras-chave: dc.subjectDNA damage-
Palavras-chave: dc.subjectOvertraining-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleOvertraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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