Ausência de associação entre os polimorfismos do gene interleucina-18 e artrite reumatoide

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Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFarias, Ticiana Della Justina-
Autor(es): dc.creatorDo Cantoa, Luisa Matos-
Autor(es): dc.creatorMedeiros, Mayara Delagnelo-
Autor(es): dc.creatorSereia, Aline Fernanda Rodrigues-
Autor(es): dc.creatorBack, Lia Kubelka Fernandes de Carlos-
Autor(es): dc.creatorDe Mello, Filipe Martins-
Autor(es): dc.creatorZimmermann, Adriana Fontes-
Autor(es): dc.creatorPereira, Ivânio Alves-
Autor(es): dc.creatorMuniz, Yara Costa Netto-
Autor(es): dc.creatorMarrero, Andrea Rita-
Autor(es): dc.creatorDe Souza, Ilíada Rainha-
Data de aceite: dc.date.accessioned2025-08-21T19:33:09Z-
Data de disponibilização: dc.date.available2025-08-21T19:33:09Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2013-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0482-50042013000200007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231302-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231302-
Descrição: dc.descriptionObjective: To assess the association of the polymorphisms of the interleukin-18 (IL-18) gene with rheumatoid arthritis (RA) and with risk factors for cardiovascular diseases (CVD). Methods: This sample comprised 97 patients with RA and 151 healthy controls. In the patients, risk factors for CVD were analyzed, such as cholesterol levels, arterial hypertension, smoking habit, C-reactive protein (CRP) level, and rheumatoid factor. DNA was extracted and the single nucleotide polymorphisms (SNP) at the -607C/A and -137G/C positions of the IL-18 gene were assessed in both groups. The Hardy-Weinberg equilibrium (HWE) was calculated and the odds ratio (OR) test performed, considering a 95% CI and P < 0.05. Results: The frequencies of the -607A allele in patients with RA and in controls were 0,443 and 0.424, respectively, and of the -137C allele, 0.304 and 0.291, respectively. The genotype frequencies were in HWE, except for controls in the -137 locus (P = 0.006). Association of the polymorphisms of the IL-18 gene was found with neither RA nor risk factors for CVD, including cholesterol level and CRP (P > 0.05). In addition, more smokers were found among patients with RA as compared with controls (OR = 1.691; P = 0.088), and the CRP levels were slightly higher in patients who smoked than in patients who did not (OR = 2.673; P = 0.061). Conclusions: In this sample of patients with RA in the South of Brazil, association of the polymorphisms of the IL-18 gene was observed with neither RA nor risk factors for CVD. ©2013 Elsevier Editora Ltda.-
Descrição: dc.descriptionLaboratório de Polimorfismos Genéticos Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC-
Descrição: dc.descriptionHospital das Clínicas Faculdade de Medicina Universidade do Estado de São Paulo (HC-FMUSP), São Paulo, SP-
Descrição: dc.descriptionServiço de Reumatologia Hospital Universitário Universidade Federal de Santa Catarina (HU-UFSC), Florianópolis, SC-
Formato: dc.format199-205-
Idioma: dc.languagept_BR-
Relação: dc.relationRevista Brasileira de Reumatologia-
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Palavras-chave: dc.subjectBrazil-
Palavras-chave: dc.subjectCardiovascular diseases-
Palavras-chave: dc.subjectGene polymorphism-
Palavras-chave: dc.subjectInterleukin-18-
Palavras-chave: dc.subjectRheumatoid arthritis-
Título: dc.titleAusência de associação entre os polimorfismos do gene interleucina-18 e artrite reumatoide-
Título: dc.titleLack of association between interleukin-18 polymorphisms and rheumatoid arthritis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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