Analysis of the TAX1BP1 gene in head and neck cancer patients

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Autor(es): dc.contributorFAMERP-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSão José do Rio Preto-
Autor(es): dc.contributorUPGEM-
Autor(es): dc.contributorCentro Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Autor(es): dc.creatorRuiz, Mariangela Torreglosa-
Autor(es): dc.creatorBalachi, Janayna Fernanda-
Autor(es): dc.creatorFernandes, Raquel Aldrighi-
Autor(es): dc.creatorGalbiatti, Ana Lívia Silva-
Autor(es): dc.creatorManigua, José Victor-
Autor(es): dc.creatorPavarino-Bertelli, Érika Cristina-
Autor(es): dc.creatorGoloni-Bertollo, Eny Maria-
Data de aceite: dc.date.accessioned2025-08-21T17:55:49Z-
Data de disponibilização: dc.date.available2025-08-21T17:55:49Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2010-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1808-86942010000200008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231247-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231247-
Descrição: dc.descriptionIn Brazil, there were I4,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGenetics and Molecular Biology Unit Medical School FAMERP-
Descrição: dc.descriptionUNESP São José do Rio Preto-
Descrição: dc.descriptionMedical School São José do Rio Preto FAMERP-
Descrição: dc.descriptionUNORP São José do Rio Preto-
Descrição: dc.descriptionDepartment of Otolaryngology and Head and Neck Surgery-
Descrição: dc.descriptionDepartment of Human Genetics-
Descrição: dc.descriptionMolecular Biology Department Medical School FAMERP-
Descrição: dc.descriptionUnidade de Pesquisa em Genética e Biologia Molecular UPGEM, Av. Brigadeiro Faria Lima 5416 bloco U-6, São José do Rio Preto 15090-000-
Descrição: dc.descriptionFundação de Amparo À Pesquisa do Estado de São Paulo (FAPESP) Centro Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUNESP São José do Rio Preto-
Formato: dc.format193-198-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Otorhinolaryngology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlcohol drinking-
Palavras-chave: dc.subjectGenetics-
Palavras-chave: dc.subjectHead and neck neoplasms-
Palavras-chave: dc.subjectTobacco-
Título: dc.titleAnalysis of the TAX1BP1 gene in head and neck cancer patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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