Influence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Säo Paulo-
Autor(es): dc.contributorRua Vivaldo Guimarães-
Autor(es): dc.creatorBonfante, Samara-
Autor(es): dc.creatorBosco, Alvaro Francisco-
Autor(es): dc.creatorLuize, Danielle Shima-
Autor(es): dc.creatorDe Almeida, Juliano Milanezi-
Autor(es): dc.creatorCestari, Tania Mary-
Autor(es): dc.creatorTaga, Rumio-
Data de aceite: dc.date.accessioned2025-08-21T22:23:16Z-
Data de disponibilização: dc.date.available2025-08-21T22:23:16Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2008-05-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231114-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231114-
Descrição: dc.descriptionPurpose: The aim of this study was to perform qualitative and quantitative analyses of the effect of nicotine on autogenous bone block grafts and to describe events in the initial healing phase and the differences in the repair processes between animals exposed to nicotine and controls. Materials and Methods: Forty-eight female Wistar rats were randomly divided into 2 groups, the nicotine group and the saline group. All animals received either nicotine (3 mg/kg) or saline 4 weeks before the surgical procedure and continued to receive nicotine from surgery to sacrifice at 7, 14, or 28 days. The autogenous bone block graft was harvested from the calvaria and stabilized on the external cortical area near the angle of the mandible. Results: The histologic analyses of the nicotine group depicted a delay in osteogenic activity at the bed-graft interface, as well as impairment of the organization of the granulation tissue that developed instead of blood clot. Nicotine-group specimens exhibited less bone neoformation, and the newly formed bone was poorly cellularized and vascularized. The histometric analysis revealed significantly less bone formation in the nicotine group at both 14 days (23.75% ± 6.18% versus 51.31% ± 8.31%) and 28 days (42.44% t 8.70% versus 73.00% ± 4.99%). Conclusion: Nicotine did Jeopardize the early healing process of autogenous bone block grafts in rats but did not prevent it.-
Descrição: dc.descriptionDental School of Araçatuba University of São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru Dental School University of Säo Paulo-
Descrição: dc.descriptionRua Vivaldo Guimarães, no 17-62 Jardim Dona Sarah, CEP:17012-120, Bauru, São Paulo-
Formato: dc.format437-444-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Oral and Maxillofacial Implants-
Relação: dc.relation14707-
Relação: dc.relation234699-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutograft-
Palavras-chave: dc.subjectBone grafting-
Palavras-chave: dc.subjectNicotine-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleInfluence of nicotine on healing process of autogenous bone block grafts in the mandible: A histomorphometric study in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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