The influence of cyclosporin A on mechanical retention of dental implants previously integrated to the bone: A study in rabbits

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorEducational Foundation of Barretos-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSakakura, Celso E.-
Autor(es): dc.creatorMargonar, Rogerio-
Autor(es): dc.creatorSartori, Rafael-
Autor(es): dc.creatorMorais, Juliana A.N.D.-
Autor(es): dc.creatorMarcantonio Jr., Elcio-
Data de aceite: dc.date.accessioned2025-08-21T18:52:28Z-
Data de disponibilização: dc.date.available2025-08-21T18:52:28Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2006-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1902/jop.2006.050290-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231027-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231027-
Descrição: dc.descriptionBackground: Immunosuppressive agents may induce severe changes on bone metabolism and may impair the osseointegration process during the implant healing. No data are available concerning the influence of cyclosporin A on dental implants previously integrated to the bone. The aim of this study was to evaluate the influence of cyclosporin A administration on the mechanical retention of bone previously integrated to dental implants. Methods: Eighteen female New Zealand rabbits were submitted to an implant surgery. Each animal received one commercial dental implant of 10 × 3.75 mm. After 12 weeks of an undisturbed healing period, six animals were randomly sacrificed and the removal torque test was performed (group A). In addition, six animals were submitted to a daily injection of cyclosporin A in a dosage of 10 mg/kg (group C), and six animals received saline solution as a control (group B). After 12 weeks of cyclosporin A administration, groups B and C were sacrificed and submitted to a removal torque test in which higher values can be interpreted as higher mechanical bone retention to the implant surface or higher osseointegration. Results: The removal torque results were 30.5 (±9.8) Ncm for group A, 50.17 (±17.5) Ncm for group B, and 26 (±7.8) Ncm for group C. The statistical analysis showed significant differences between groups A and B (P <0.05) and groups B and C (P<0.01). Conclusion: Cyclosporin A administration may impair the mechanical retention of dental implants previously integrated to the bone.-
Descrição: dc.descriptionDepartment of Periodontology Educational Foundation of Barretos, Barretos, São Paulo-
Descrição: dc.descriptionDepartment of Periodontology Dental School of Araraquara State University of São Paulo, Rua Humaitá 1680, Araraquara, São Paulo-
Formato: dc.format2059-2062-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCyclosporin A-
Palavras-chave: dc.subjectDental implant-
Palavras-chave: dc.subjectOsseointegration-
Palavras-chave: dc.subjectTorque-
Título: dc.titleThe influence of cyclosporin A on mechanical retention of dental implants previously integrated to the bone: A study in rabbits-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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