Chlorhexidine arrests subclinical degradation of dentin hybrid layers in vivo

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorMedical College of Georgia-
Autor(es): dc.contributorUniversity of Helsinki-
Autor(es): dc.contributorHelsinki University Central Hospital (HUCH)-
Autor(es): dc.contributorPrince Philip Dental Hospital-
Autor(es): dc.creatorHebling, J.-
Autor(es): dc.creatorPashley, D. H.-
Autor(es): dc.creatorTjäderhane, L.-
Autor(es): dc.creatorTay, F. R.-
Data de aceite: dc.date.accessioned2025-08-21T17:12:20Z-
Data de disponibilização: dc.date.available2025-08-21T17:12:20Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2005-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/154405910508400811-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231010-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231010-
Descrição: dc.descriptionThe recent paradigm that endogenous collagenolytic and gelatinolytic activities derived from acid-etched dentin result in degradation of hybrid layers requires in vivo validation. This study tested the null hypothesis that there is no difference between the degradation of dentin bonded with an etch-and-rinse adhesive and that in conjunction with chlorhexidine, an MMP inhibitor, applied after phosphoric-acid-etching. Contralateral pairs of bonded Class I restorations in primary molars of clinical subjects were retrieved after a six-month period of intra-oral functioning and processed for transmission electron microscopy. Hybrid layers from the chlorhexidine-treated teeth exhibited normal structural integrity of the collagen network. Conversely, abnormal hybrid layers were seen in the control teeth, with progressive disintegration of the fibrillar network, to the extent that it was beyond detection by collagen staining. Self-destruction of collagen matrices occurs rapidly in resin-infiltrated dentin in vivo and may be arrested with the use of chlorhexidine as an MMP inhibitor.-
Descrição: dc.descriptionDepartment of Orthodontics and Pediatric Dentistry University of São Paulo State Araraquara Dental School, São Paulo-
Descrição: dc.descriptionDepartment of Oral Biology and Maxillofacial Pathology School of Dentistry Medical College of Georgia, Augusta, GA-
Descrição: dc.descriptionInstitute of Dentistry University of Helsinki-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Diseases Helsinki University Central Hospital (HUCH)-
Descrição: dc.descriptionPediatric Dentistry and Orthodontics University of Hong Kong Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong-
Formato: dc.format741-746-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dental Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCollagenolysis-
Palavras-chave: dc.subjectGelatinolysis-
Palavras-chave: dc.subjectHybrid layer-
Palavras-chave: dc.subjectMMPs-
Palavras-chave: dc.subjectPrimary dentin-
Título: dc.titleChlorhexidine arrests subclinical degradation of dentin hybrid layers in vivo-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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