Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of State of São Paulo-
Autor(es): dc.creatorHolzhausen, Marinella-
Autor(es): dc.creatorPalomari Spolidorio, Denise M.-
Autor(es): dc.creatorMuscará, Marcelo Nicolás-
Autor(es): dc.creatorHebling, Josimery-
Autor(es): dc.creatorSpolidorio, Luis Carlos-
Data de aceite: dc.date.accessioned2025-08-21T16:15:52Z-
Data de disponibilização: dc.date.available2025-08-21T16:15:52Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2005-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2005.00787.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230984-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230984-
Descrição: dc.descriptionBackground: The purpose of the present study was to evaluate the effect of a potent selective cyclooxygenase-2 (COX-2) inhibitor, etoricoxib, on the prevention of alveolar bone loss in experimental periodontitis induced in rats. Methods: Ninety Wistar rats were separated into three experimental groups. Cotton ligatures were placed at the gingival margin level of lower right first molars. The rats were randomly assigned to one of the following groups: control received a daily oral dose of 1 ml/kg of saline solution; Eto1 received 6 mg/kg of etoricoxib; Eto2 received 12 mg/kg of etoricoxib. Serum levels of etoricoxib and white blood cells were determined. Standardized digital radiographs were taken after death at 3, 5, 10, 18 and 30 days to measure the amount of bone loss at the mesial root surface of the first molar tooth in each rat. Results: One-way analysis of variance (ANOVA) indicated that groups treated with both doses of etoricoxib had significantly (p < 0.05) less alveolar bone loss when compared to controls. Furthermore, etoricoxib treatment significantly inhibited the leukocytosis observed 3 days after the induction of periodontitis. Conclusion: These data provide evidence that systemic therapy with etoricoxib can retard alveolar bone loss in a ligature-induced periodontitis model in rats. © Blackwell Munksgaard 2005.-
Descrição: dc.descriptionDepartment of Periodontology Dental School of Araraquara State University of São Paulo, Araraquara, São Paulo-
Descrição: dc.descriptionDepartments of Physiology and Pathology Dental School of Araraquara State University of São Paulo, Araraquara, São Paulo-
Descrição: dc.descriptionDepartments of Orthodontics and Pediatric Dentistry Dental School of Araraquara State University of São Paulo, Araraquara, São Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biomedical Sciences University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Pathology University of State of São Paulo, R. Humaitá, 1680, C.P. 331, Araraquara, SP, CEP: 14801-903-
Formato: dc.format208-211-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontal Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlveolar bone loss-
Palavras-chave: dc.subjectControl-
Palavras-chave: dc.subjectCyclooxygenase inhibitors-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPrevention-
Título: dc.titleProtective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats-
Tipo de arquivo: dc.typelivro digital-
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