Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorLaboratory of Rheumatology-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHaematology Unit-
Autor(es): dc.contributorRheumatology Unit-
Autor(es): dc.creatorSampaio-Barros, Percival D.-
Autor(es): dc.creatorConde, Roseneide A.-
Autor(es): dc.creatorDonadi, Eduardo A.-
Autor(es): dc.creatorKraemer, Maria Helena S.-
Autor(es): dc.creatorPersoli, Ligia-
Autor(es): dc.creatorCoimbra, Ibsen B.-
Autor(es): dc.creatorCostallat, Lilian Teresa L.-
Autor(es): dc.creatorSamara, Adil M.-
Autor(es): dc.creatorBértolo, Manoel B.-
Data de aceite: dc.date.accessioned2025-08-21T16:42:26Z-
Data de disponibilização: dc.date.available2025-08-21T16:42:26Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2003-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230960-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230960-
Descrição: dc.descriptionObjective. To analyze the profile of the HLA-B27 and B7 cross-reactive group (CREG) alleles and the role of these markers in disease characterization and progression in patients with undifferentiated spondyloarthropathies (uSpA). Methods. A total of 80 patients with a diagnosis of uSpA (40 HLA-B27 positive and 40 HLA-B27 negative) were prospectively studied for 2 years. The control group consisted of 66 HLA-B27 positive and 112 HLA-B27 negative individuals without a history of seronegative SpA. HLA-B alleles were typed at low (B7-CREG alleles, i.e., B*7, B*54, B*55, B*56, B*40, B*42) or high resolution (B*27 alleles) using polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes. Results. HLA-B*2705 was the most frequent allele, observed in 92.5% of the patients and in 77% of the controls, followed by the HLA-B*2702, observed in 5% of the patients and in 12% of the controls. HLA-B*2704 was observed in only one patient (2.5%), and was absent in the control population. HLA-B*2703 (6%) and HLA-B*2707 (5%) alleles were observed only in controls. No associations between HLA-B*27 alleles or B7-CREG alleles and any specific manifestation of uSpA were observed. HLA-B27 positive patients more frequently presented juvenile onset SpA (p = 0.002) and progression to ankylosing spondylitis (AS) (p = 0.03) than did HLA-B27 negative patients. The B7-CREG alleles were observed in 5% of the HLA-B27 positive uSpA group, in 25% of the HLA-B27 negative uSpA group, in 7% of the HLA-B27 positive controls, and in 13% of the HLA-B27 negative controls; a significant association was observed between the presence of the B7-CREG and the HLA-B27 negative uSpA group (p = 0.012). Conclusion. The frequency of the HLA-B*2705 allele among the B27 positive uSpA patients of this series was closely similar to that reported for patients with ankylosing spondylitis (AS). The presence of HLA-B*27 alleles was associated with the progression to AS, and the presence of B7-CREG was associated with uSpA in the HLA-B27 negative group.-
Descrição: dc.descriptionDepartment of Internal Medicine State University of Campinas Faculty of Medical Sciences, Campinas-
Descrição: dc.descriptionLaboratory of Rheumatology-
Descrição: dc.descriptionImmunology Unit State University of Sao Paulo, Ribeirão Preto-
Descrição: dc.descriptionDepartment of Clinical Pathology-
Descrição: dc.descriptionHaematology Unit-
Descrição: dc.descriptionRheumatology Unit-
Descrição: dc.descriptionDepartment of Rheumatology-
Descrição: dc.descriptionRheumatology Unit Faculty of Medical Sciences State University of Campinas, Campinas-
Descrição: dc.descriptionDepartamento de Clinica Medica Faculdade de Ciencias Medicas Univ. Estadua de Campinas (UNICAMP), Campinas SP, CEP 13081-970-
Formato: dc.format2632-2637-
Idioma: dc.languageen-
Relação: dc.relationJournal of Rheumatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlleles-
Palavras-chave: dc.subjectFollowup-
Palavras-chave: dc.subjectHLA-B27-
Palavras-chave: dc.subjectSpondyloarthropathies-
Palavras-chave: dc.subjectUndifferentiated spondyloarthropathies-
Título: dc.titleUndifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression-
Tipo de arquivo: dc.typelivro digital-
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