Pharmacological evidence that methylene blue inhibits noradrenaline neuronal uptake in the rat vas deferens

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Medicine of Marília-
Autor(es): dc.contributorSchool of Medicine of Ribeirao Preto-
Autor(es): dc.contributorBiosciences Institute of Botucatu-
Autor(es): dc.creatorChies, Agnaldo B.-
Autor(es): dc.creatorCustódio, Ricardo C.-
Autor(es): dc.creatorde Souza, Gregório-
Autor(es): dc.creatorCorrêa, Fernando M.A.-
Autor(es): dc.creatorPereira, Oduvaldo C.M.-
Data de aceite: dc.date.accessioned2025-08-21T18:01:55Z-
Data de disponibilização: dc.date.available2025-08-21T18:01:55Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2003-10-09-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230951-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230951-
Descrição: dc.descriptionWe report that the classical guanylate cyclase inhibitor methylene blue (MB, 1 μM or 10 μM), but not the selective guanylate cyclase inhibitor 1H-[1,2,4]oxidazolo[4,3-a]quinoxalin-1-one (1 μM) or nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (100 μM), causes a shift to the left in the concentration-response curve for noradrenaline in the isolated rat vas deferens preparations. The main objective of our study was to investigate the pharmacological mechanism by which MB increases the sensitivity of the rat vas deferens to noradrenaline. According to the presented results, MB did not change rat vas deferens sensitivity to methoxamine or noradrenaline in the presence of desipramine (0.1 μM). The pre-contracted rat vas deferens relaxation induced by isoproterenol was also not significantly changed by MB (1 μM). Thus, we suggest that MB increases rat vas deferens sensitivity through neuronal uptake inhibition without interfering in either the nitrergic mechanism or guanylate cyclase activity.-
Descrição: dc.descriptionLaboratory of Pharmacology School of Medicine of Marília, Marília 17519-030 SP-
Descrição: dc.descriptionDepartment of Pharmacology School of Medicine of Ribeirao Preto, Ribeirão Preto 14049-900 SP-
Descrição: dc.descriptionDepartment of Pharmacology Biosciences Institute of Botucatu, Botucatu 18.618-000 SP-
Formato: dc.format573-579-
Idioma: dc.languageen-
Relação: dc.relationPolish Journal of Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGuanylate cyclase-
Palavras-chave: dc.subjectMethylene blue-
Palavras-chave: dc.subjectNeuronal uptake-
Palavras-chave: dc.subjectNoradrenaline-
Palavras-chave: dc.subjectRat vas deferens-
Título: dc.titlePharmacological evidence that methylene blue inhibits noradrenaline neuronal uptake in the rat vas deferens-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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