Histogenesis of the cysts in the autosomal dominant polycystic kidney disease: An immunohistochemical study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorMarilia School of Medicine-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.creatorTherezo, Altino Luiz Silva-
Autor(es): dc.creatorBacchi, Carlos Eduardo-
Autor(es): dc.creatorFranco, Marcello-
Data de aceite: dc.date.accessioned2025-08-21T15:27:32Z-
Data de disponibilização: dc.date.available2025-08-21T15:27:32Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued1998-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/00022744-199812000-00008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230900-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230900-
Descrição: dc.descriptionThe histogenesis of the cysts in the autosomal dominant polycystic kidney disease was investigated in 33 patients by immunohistochemistry. The antibodies and lectins used to identify the different segments of the nephrons were as follows: vimentin-parietal epithelium of the glomerular capsule; lotus tetragonolubus agglutinin and anti-CD15-proximal tubule; anti- Tamm-Horsfall protein (THP)-distal tubule (DT); anti-epithelial membrane antigen, anti-cytokeratin 19, Ulex europaeus agglutinin, Arachis hypogaea agglutinin (PNA), Dolichos biflorus agglutinin and Glycine maximum agglutinin (SBA)-DT and collecting duct. In a pilot study, we analyzed three normal autopsy kidneys (control kidneys) and noninvolved areas of two kidneys with autosomal dominant polycystic kidney disease (internal control) and observed in all cases that glomerular capsule stained with vimentin, proximal tubule with lotus tetragonolubus agglutinin and CD15, DT with THP, DT and collecting duct with epithelial membrane antigen, anti-cytokeratin 19, Ulex europaeus- I, PNA, and Dolichos biflorus agglutinin. SBA was nonreactive. The 49 kidneys with autosomal dominant polycystic kidney disease gave the following immunohistochemical profile: (a) noninvolved areas: antivimentin-glomerular capsule = 82%; lotus tetragonolubus agglutinin-proximal tubule = 96%; anti- CD15-proximal tubule = 100%; anti-THP-DT = 96%; anti-epithelial membrane antigen-DT and collecting duct = 90% and 93%, respectively, and anti- cytokeratin 19-DT and collecting duct = 86% and 89% of the cases, respectively; (b) cystic areas: lotus tetrago- nolubus agglutinin, anti- CD15, anti-PTH, anti-epithelial membrane antigen, and anti-cytokeratin 19 = 7, 6, 18, 97, and 95% of the cases, respectively. Anti-vimentin was nonreactive. The results indicated that the cysts in cases of autosomal dominant polycystic kidney disease have an immunohistochemical profile of distal tubules and collecting ducts.-
Descrição: dc.descriptionDepartment of Pathology Marilia School of Medicine, São Paulo-
Descrição: dc.descriptionDepartment of Pathology Botucatu School of Medicine University of São Paulo State, São Paulo-
Descrição: dc.descriptionDepartment of Pathology Paulista School of Medicine Federal University of São Paulo, São Paulo-
Descrição: dc.descriptionDepto. Patologia EPM/UNIFESP, Rua Botucatu, 740, Vila Clementino, São Paulo-Capital-
Formato: dc.format219-223-
Idioma: dc.languageen-
Relação: dc.relationApplied Immunohistochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutosomal dominant polycystic kidney disease-
Palavras-chave: dc.subjectHistogenesis-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectLectins-
Título: dc.titleHistogenesis of the cysts in the autosomal dominant polycystic kidney disease: An immunohistochemical study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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