AIDS-related lymphoma in Brazil: Histopathology, immunophenotype, and association with Epstein-Barr virus

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorCity of Hope National Medical Center-
Autor(es): dc.contributorUniversity of Washington-
Autor(es): dc.creatorBacchi, Carlos E.-
Autor(es): dc.creatorBacchi, Maura M.-
Autor(es): dc.creatorRabenhorst, Silvia H.-
Autor(es): dc.creatorSoares, Fernando A.-
Autor(es): dc.creatorFonseca Jr., Luciano E.-
Autor(es): dc.creatorBarbosa, Helenemarie S.-
Autor(es): dc.creatorWeiss, Lawrence M.-
Autor(es): dc.creatorGown, Allen M.-
Data de aceite: dc.date.accessioned2025-08-21T22:28:04Z-
Data de disponibilização: dc.date.available2025-08-21T22:28:04Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued1996-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/ajcp/105.2.230-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230891-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230891-
Descrição: dc.descriptionThe occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several types of immunodeficiency-related lymphomas and Epstein-Barr virus (EBV), the association of EBV infection in AIDS-related lymphoma in Brazil, where the incidence of AIDS is high, is unknown. Formalin-fixed, paraffin-embedded tissue from 24 cases of AIDS-related lymphoma in Brazil were analyzed for morphologic classification, immunophenotype, and EBV association using in situ hybridization studies with an EBV-EBERI biotinylated probe. Twenty cases of AIDS-related lymphoma were classified as non-Hodgkin's lymphoma and four cases were Hodgkin's disease. Eleven non- Hodgkin's lymphomas were classified as diffuse large cell type, five cases were small non-cleaved cell, Burkitt-type, and four cases were large cell immunoblastic non-Hodgkin's lymphoma. Eighteen cases were of B-cell phenotype; one was a T-cell lymphoma, and one was classified as null. Epstein-Barr virus (EBV) was demonstrated in the majority of tumor cells of 11 of 20 (55%) of the cases non-Hodgkin's lymphomas and in 3 of 4 (75%) cases of Hodgkin's disease. AIDS-related lymphomas in Brazil are usually of large cell/immunoblastic type, but Hodgkin's disease is also seen. Both non- Hodgkin's lymphoma and Hodgkin's disease are often associated with EBV infection. The non-Hodgkin's lymphoma is predominantly of B-cell phenotype.-
Descrição: dc.descriptionWhile there is a clear association between several types of immunodeficiency-related lymphomas and Epstein-Barr virus (EBV), the association of EBV infection in AIDS-related lymphoma in Brazil, where the incidence of AIDS is high, has remained unknown. The authors report their findings from an analysis of tissue samples from 24 cases of AIDS-related lymphoma in Brazil. The samples were analyzed for morphologic classification, immunophenotype, and EBV association. 20 cases were classified as non-Hodgkin's lymphoma, while 4 were Hodgkin's disease. 11 non-Hodgkin's lymphomas were classified as diffuse large cell type, 5 as small, non-cleaved cell, Burkitt-type, and 4 as large cell immunoblastic non-Hodgkin's lymphoma. 18 cases were of B-cell phenotype; one was a T-cell lymphoma and one was classified as null. EBV was demonstrated in the tumor cells of 11 of the 20 non-Hodgkin's lymphoma cases and in 3 of the 4 cases of non-Hodgkin's disease.-
Descrição: dc.descriptionDepartments of Pathology State University of Sao Paulo, Botucatu, Sao Paulo-
Descrição: dc.descriptionUniversity of Sao Paulo, Ribeirao Preto, Sao Paulo-
Descrição: dc.descriptionFederal University of Bahia-
Descrição: dc.descriptionCity of Hope National Medical Center, Duarte, CA-
Descrição: dc.descriptionUniversity of Washington, Seattle, WA-
Formato: dc.format230-237-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Clinical Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAIDS-
Palavras-chave: dc.subjectEBV-
Palavras-chave: dc.subjectHIV-
Palavras-chave: dc.subjectHodgkin's disease-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectIn situ hybridization-
Palavras-chave: dc.subjectLymphoma-
Título: dc.titleAIDS-related lymphoma in Brazil: Histopathology, immunophenotype, and association with Epstein-Barr virus-
Tipo de arquivo: dc.typelivro digital-
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