α1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorQueiroz-Neto, Antonio-
Autor(es): dc.creatorBallejo, Gustavo-
Data de aceite: dc.date.accessioned2025-08-21T20:39:28Z-
Data de disponibilização: dc.date.available2025-08-21T20:39:28Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued1993-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/0306-3623(93)90362-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230879-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230879-
Descrição: dc.description1. The effects of chlorethylclonidine (CEC), 5-methyl-urapidil (5-MU), ryanodine and prolonged exposition to norepinephrine (NE) on the concentration-response curves (CRC) to this agonist on the bisected rat vas deferens (RVD) were investigated. 2. CEC did not affect the 50% effective concentration (EC50) of NE in either the prostatic (PP) or the epididymal (EP) portions of the RVD. 3. 5-MU did not alter the EC50 of NE in the PP but caused a significant and concentration-dependent rightward shift of the CRC to NE in the EP. 4. Ryanodine caused a shift to the right of the CRC to NE in the PP associated to a decrease in maximal response, but did not affect the CRC to NE in the EP. 5. Incubation of the EP with NE for 6 hr elicited a significant decrease in the maximal response with no changes in the EC50. Similar treatment of the PP was associated with a significant shift to the right of the CRC to NE without modifications in the maximal response. 6. These results suggest that in the RVD, NE interacts with two different α1-adrenoceptors subtypes which are disposed in a selective manner along the RVD: the α1a subtype in the EP, and a non-α1b-non-α1a adrenoceptor subtype mainly located at the PP. © 1993.-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology, Faculty of Agronomic and Veterinary Sciences, University of São Paulo State-UNESP, Jaboticabal, 14870-000, Brazil [Fax (0163) 22-4275]-
Descrição: dc.descriptionFaculty of Medicine of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto-
Formato: dc.format1149-1153-
Idioma: dc.languageen-
Relação: dc.relationGeneral Pharmacology-
???dc.source???: dc.sourceScopus-
Título: dc.titleα1-Adrenoceptor subtypes mediating the norepinephrine-induced contractile response in the rat vas deferens-
Tipo de arquivo: dc.typelivro digital-
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