Nociceptive modulation in rats by chemical stimulation of caudate, septum and medial forebrain bundle

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorVeterinary School of Jaboticabal-
Autor(es): dc.contributorSchool of Medicine of Ribeirão-
Autor(es): dc.creatorMacari, M.-
Autor(es): dc.creatorLico, M. C.-
Data de aceite: dc.date.accessioned2025-08-21T15:53:08Z-
Data de disponibilização: dc.date.available2025-08-21T15:53:08Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued1980-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/0031-9384(80)90136-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230797-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230797-
Descrição: dc.descriptionThe effects of intracerebral microinjections of Thiopental (25 μg) and Metrazol (100 μg) on the defensive motor responses elicited by nociceptive electrical stimulation of the rat's tail were determined. Also, the action of these drugs on the concentration of catecholamines in the injected areas were evaluated by the freeze-drying histofluorescence method. Albino, Holtzman rats implanted with cannulae in the caudate nucleus, medial septal area and medial forebrain bundle were used. The animals were studied following control conditions and after the drug injections. Thiopental show an antinociceptive action when injected into the medial septal area and MFB, and hyperalgesic effect when injected into the caudate nucleus. Metrazol (Pentylenetetrazol) into the medial septal area and caudate nucleus produced hyperalgesia, and analgesia when injected into the MFB. The histochemical study for catecholamines revealed decreases in DA levels in the MFB and caudate nucleus and decreases in the NA in the medial septal area after injections of both drugs. The results are discussed in terms of neuropathways and neurotransmitters involved in nociception. © 1980.-
Descrição: dc.descriptionDepartment of Morphology and Physiology Veterinary School of Jaboticabal, 14870-
Descrição: dc.descriptionDepartment of Physiology School of Medicine of Ribeirão, Preto, 14100 SP-
Formato: dc.format833-837-
Idioma: dc.languageen-
Relação: dc.relationPhysiology and Behavior-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaudate-
Palavras-chave: dc.subjectChemical stimulation-
Palavras-chave: dc.subjectMedial forebrain bundle-
Palavras-chave: dc.subjectNociceptive modulation-
Palavras-chave: dc.subjectSeptum-
Título: dc.titleNociceptive modulation in rats by chemical stimulation of caudate, septum and medial forebrain bundle-
Tipo de arquivo: dc.typelivro digital-
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