Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVassilieff, I.-
Autor(es): dc.creatorDe Oliveira Vassilieff, V. S.-
Autor(es): dc.creatorChagas, A. M.-
Data de aceite: dc.date.accessioned2025-08-21T16:42:14Z-
Data de disponibilização: dc.date.available2025-08-21T16:42:14Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued1979-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230792-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230792-
Descrição: dc.descriptionMethoxyflurane (0.2 ml/kg over 5 min), administered by inhalation to dogs with spontaneous respiration, resulted approximately 10 minutes later in a significant increase of intraocular pressure (IOP) (13.3 mm Hg), cerebrospinal fluid pressure (CSFP) (9.4 mm Hg), and venous pressure (VP) (6 mm Hg), as well as a significant decrease in arterial pressure (AP) (23.3 mm Hg), respiratory frequency (3.2 mov/min) and respiratory amplitude (7.1 mm). These alterations occurred concomitantly with respiratory acidosis, an increase in serum K+ and Cl-, increased osmolarity of the aqueous humor, and an elevation of K+ and Cl- in cerebrospinal fluid (CSF). However, if CSF was allowed to drain freely so that no increase of CSFP occurred, there was only a small increase of IOP (3.7 mm Hg). Under these latter conditions, there also was a decrease of arterial pressure (20.7 mm Hg), respiratory frequency (9.5 mov/min) and respiratory amplitude (2.1 mm). When dogs were ventilated artificially the above changes were greatly attenuated. They were limited to a small but significant rise of CSFP (4.7 mm Hg), a decrease in AP (20.7 mm Hg) and a decrease of HCO3- (7.6 mEq/) of arterial blood. The possible mechanisms involved in the action of methoxyflurane on IOP were discussed and it was pointed out that this anesthetic agent might be used for inducing anesthesia; however, it would be necessary to avoid respiratory depression, in order to prevent intracranial and ocular hypertension.-
Descrição: dc.descriptionDept. Farmacol., Inst. Bas. Biol., Med. Agric. Campus Botucatu, Univ. Estad. Paulista Julio de Mesquita Filho, Botucatu-
Formato: dc.format33-39-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleEffects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration-
Tipo de arquivo: dc.typelivro digital-
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