Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBellot, Marina Sanson-
Autor(es): dc.creatorGuermandi, Isabela Inforzato-
Autor(es): dc.creatorCamargo-dos-Santos, Bruno-
Autor(es): dc.creatorGiaquinto, Percília Cardoso-
Data de aceite: dc.date.accessioned2025-08-21T22:37:45Z-
Data de disponibilização: dc.date.available2025-08-21T22:37:45Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-02-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fnbeh.2022.810051-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230559-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230559-
Descrição: dc.descriptionIndividuals differ in their preference for alcohol and propensity to develop alcoholism, where the behavioral profile, such as the bold-shy axis, plays an important role for such a difference. However, literature is limited and conflicting on the causes and consequences of this relationship. Translational studies using animal models, such as zebrafish, can help identify behavioral traits that predispose individuals to drink alcohol compulsively. Here, the preference for alcohol was investigated in two distinct traits in zebrafish: shy and bold. For this purpose, fish were separated into shy and bold traits and then a conditioned place preference paradigm was used, a strategy that allows the rewarding effects from alcohol to be assessed by the ability to enhance the animal’s preference for an environment that initially was not preferred. It was found that bold zebrafish actively searched for the environment that was paired to alcohol after one acute exposure, whereas, shy fish changed their place preference even without alcohol administration, showing that the conditioned place preference protocol, given the short amount time to assess place preference, is not ample enough for shy fish to choose. Our results show that behavioral profiles must be considered in further studies since differences between shy and bold individuals on preference behavior can strongly interfere in the assessment of drug preference, mainly when using the conditioned place preference paradigm.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, Botucatu-
Descrição: dc.descriptionAquaculture Center of Unesp São Paulo State University, Jaboticabal-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, Botucatu-
Descrição: dc.descriptionAquaculture Center of Unesp São Paulo State University, Jaboticabal-
Descrição: dc.descriptionFAPESP: 2019/19952-8-
Descrição: dc.descriptionCNPq: 800571/2016-9-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Behavioral Neuroscience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalcohol preference-
Palavras-chave: dc.subjectboldness-
Palavras-chave: dc.subjectcomparative behavior-
Palavras-chave: dc.subjectconditioned place preference-
Palavras-chave: dc.subjectpersonality-
Palavras-chave: dc.subjectreinforcement-
Palavras-chave: dc.subjectreward-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titleDifferences in the Alcohol Preference Assessment of Shy and Bold Zebrafish-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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