Intergenerational high-fat diet impairs ovarian follicular development in rodents: a systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.creatorPaula, Verônyca G-
Autor(es): dc.creatorVesentini, Giovana-
Autor(es): dc.creatorSinzato, Yuri K.-
Autor(es): dc.creatorMoraes-Souza, Rafaianne Q.-
Autor(es): dc.creatorVolpato, Gustavo T.-
Autor(es): dc.creatorDamasceno, Débora C-
Data de aceite: dc.date.accessioned2025-08-21T22:50:28Z-
Data de disponibilização: dc.date.available2025-08-21T22:50:28Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-03-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/nutrit/nuab049-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230556-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230556-
Descrição: dc.descriptionCONTEXT: Excessive consumption of high-fat diets has increased in the population over time and is harmful to female fertility. OBJECTIVE: To investigate and discuss the effects of a high-fat diet on ovarian follicles in rodents. DATA SOURCE: A systematic literature search of PubMed, EMBASE, Web of Science, and SCOPUS was carried out. DATA EXTRACTION: Study characteristics, including study design, population, intervention, outcome, and risk of bias were analyzed. DATA ANALYSIS: Twenty-two articles were included in a systematic review. Given the availability of studies, a quantitative meta-analysis included 12 studies that were performed for outcomes. There was a decrease in primordial follicles in female rodents that received a high-fat diet compared with the standard diet group. The offspring of mothers exposed to a high-fat diet showed an increased number of cystic follicles and a decreased number of secondary follicles and antral follicles, compared with the control diet group. Therefore, these high-fat diet-induced follicular alterations might impair the fertility of dams and their female newborns. CONCLUSION: The consumption of a high-fat diet causes damage to ovarian follicular development, and this commitment will persist in the next generation. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42019133865.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionY.K. Sinzato D.C. Damasceno are with the Laboratory of Experimental Research on Gynecology and Obstetrics Gynecology Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University (Unesp)-
Descrição: dc.descriptionG.T. Volpato and R.Q. Moraes-Souza are with the Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)-
Descrição: dc.descriptionY.K. Sinzato D.C. Damasceno are with the Laboratory of Experimental Research on Gynecology and Obstetrics Gynecology Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University (Unesp)-
Descrição: dc.descriptionFAPESP: 2016/25207-5-
Descrição: dc.descriptionFAPESP: Process number 2016/25207-5-
Formato: dc.format889-903-
Idioma: dc.languageen-
Relação: dc.relationNutrition reviews-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcorpora lutea-
Palavras-chave: dc.subjectcysts-
Palavras-chave: dc.subjectmaternal diet-
Palavras-chave: dc.subjectmouse-
Palavras-chave: dc.subjectovary-
Palavras-chave: dc.subjectrat-
Título: dc.titleIntergenerational high-fat diet impairs ovarian follicular development in rodents: a systematic review and meta-analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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