The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBiggi, Alison Felipe Bordini-
Autor(es): dc.creatorde Oliveira, Deilson Elgui-
Data de aceite: dc.date.accessioned2025-08-21T15:51:46Z-
Data de disponibilização: dc.date.available2025-08-21T15:51:46Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biom12030397-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230537-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230537-
Descrição: dc.descriptionThe Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and tumor progression, also playing an important role in subverting immune responses against cancers. The homeostasis of the immune system is tightly regulated by inhibitory mechanisms affecting key immune effectors, such as T lymphocytes and NK cells. Collectively known as immune checkpoints, these mechanisms rely on a set of cellular receptors and ligands. These molecules may be candidate targets for immune checkpoints blockade—an emergent and promising modality of immunotherapy already proven to be valuable for a variety of human cancers. The EBV was lately suspected to interfere with the expression of immune checkpoint molecules, notably PD-1 and its ligands, found to be overexpressed in cases of Hodgkin lymphoma, nasopharyngeal, and gastric adenocarcinomas associated with the viral infection. Even though there is compelling evidence showing that the EBV interferes with other immune checkpoint regulators (e.g., CTLA-4, LAG-3, TIM-3, and VISTA), the published data are still scarce. Herein, we discuss the current state of the knowledge on how the EBV interferes with the activity of immune checkpoints regulators, as well as its implications considering the immune checkpoints blockade for clinical management of the EBV-associated malignancies, notably lymphomas.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBiosciences Institute of Botucatu São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Pathology Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionViriCan Institute for Biotechnology (IBTEC) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionBiosciences Institute of Botucatu São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Pathology Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionViriCan Institute for Biotechnology (IBTEC) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2019/14324-9-
Idioma: dc.languageen-
Relação: dc.relationBiomolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer management-
Palavras-chave: dc.subjectEBV-associated-
Palavras-chave: dc.subjectEpstein-Barr virus-
Palavras-chave: dc.subjectGastric adenocarcinomas-
Palavras-chave: dc.subjectHodgkin lymphoma-
Palavras-chave: dc.subjectImmune checkpoint blockade-
Palavras-chave: dc.subjectImmune checkpoints-
Palavras-chave: dc.subjectImmunotherapy-
Palavras-chave: dc.subjectNon-Hodgkin lymphomas-
Palavras-chave: dc.subjectViral ncRNAs-
Palavras-chave: dc.subjectViral oncoproteins-
Título: dc.titleThe Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.