Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFigueiredo, Amanda Menezes-
Autor(es): dc.creatorCardoso, Ana Carolina-
Autor(es): dc.creatorBuzati Pereira, Bruna Leticia-
Autor(es): dc.creatorCandido Silva, Renata Aparecida-
Autor(es): dc.creatorGoncalves Della Ripa, Andrea Freitas-
Autor(es): dc.creatorBachiega Pinelli, Tatiana Fernanda-
Autor(es): dc.creatorOliveira, Bruna Camargo-
Autor(es): dc.creatorMurino Rafacho, Bruna Paola-
Autor(es): dc.creatorWatanabe Ishikawa, Larissa Lumi-
Autor(es): dc.creatorAzevedo, Paula Schmidt-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorHenrique Fernandes, Ana Angelica-
Autor(es): dc.creatorMamede Zornoff, Leonardo Antonio-
Autor(es): dc.creatorMinicucci, Marcos Ferreira-
Autor(es): dc.creatorPolegato, Bertha Furlan-
Autor(es): dc.creatorRupp Paiva, Sergio Alberto-
Data de aceite: dc.date.accessioned2025-08-21T17:06:43Z-
Data de disponibilização: dc.date.available2025-08-21T17:06:43Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0264854-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230511-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230511-
Descrição: dc.descriptionMyocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Ac¸ai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of ac¸ai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% ac¸ai pulp (SA2, n = 12) and fed standard chow with 5% ac¸ai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% ac¸ai pulp (IA2, n = 12), and fed standard chow with 5% ac¸ai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Ac¸ai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P0.001; dose-dependent effect). In conclusion, ac¸ai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of ac¸ai pulp supplementation have dose-dependent effects on cardiac remodeling.-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), São Paulo-
Descrição: dc.descriptionChemistry and Biochemistry Department Institute of Biosciences Universidade Estadual Paulista (UNESP), São Paulo-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), São Paulo-
Descrição: dc.descriptionChemistry and Biochemistry Department Institute of Biosciences Universidade Estadual Paulista (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleAçai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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