Safety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversidade Estadual de Mato Grosso do Sul (UEMS)-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorJúnior, Armando Jorge-
Autor(es): dc.creatorStein, Julia-
Autor(es): dc.creatorReis, Ana Carolina Casali-
Autor(es): dc.creatorMoreira, Suyane da Silva-
Autor(es): dc.creatorManoel, Beatriz de Matos-
Autor(es): dc.creatorMota, Jonas da Silva-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T16:21:08Z-
Data de disponibilização: dc.date.available2025-08-21T16:21:08Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.phyplu.2021.100165-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230491-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230491-
Descrição: dc.descriptionBackground: Piper vicosanum (Piperaceae) is a species used in folk medicine mainly due to its anti-inflammatory and analgesic properties. However, the data available about its safety are still insufficient. Purpose: This study evaluated the toxicological profile and reproductive impacts in male rats treated with the ethanolic extract from Piper vicosanum leaves (EEPV) during a 28-day treatment. Methods: Male Wistar rats received ethanol extract of EEPV (0, 100, 200, or 300 mg/kg) by gavage for 28 consecutive days. Results: Males treated with EEPV did not exhibit clinical signs of toxicity during the treatment. Although hematological parameters were unaltered, a decrease in AST, total proteins, alkaline phosphatase and creatinine levels was observed in the treated animals. However, no evidence of histological changes was found in the liver and kidney. EEPV also induced an increase of abnormal sperm in males. Conclusion: The prolonged use of ethanolic extract of Piper vicosanum leaves affected biochemical and sperm parameters, showing that care should be taken when it is used for prolonged periods. Further studies, including a 90-day toxicity assay, should be performed.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionCollege of Health Science Federal University of Grande Dourados, Mato Grosso do Sul-
Descrição: dc.descriptionMato Grosso do Sul State University UEMS, Mato Grosso do Sul State-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPhytomedicine Plus-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiochemical parameters-
Palavras-chave: dc.subjectMale rats-
Palavras-chave: dc.subjectPiper-
Palavras-chave: dc.subjectReproductive toxicity-
Palavras-chave: dc.subjectSafety evaluation-
Palavras-chave: dc.subjectSperm morphology-
Título: dc.titleSafety assessment of the ethanolic extract from Piper vicosanum yunck leaves in male rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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