Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorOrtecho-Zuta, Uxua-
Autor(es): dc.creatorde Oliveira Duque, Carla Caroline-
Autor(es): dc.creatorde Oliveira Ribeiro, Rafael Antonio-
Autor(es): dc.creatorLeite, Maria Luísa-
Autor(es): dc.creatorSoares, Diana Gabriela-
Autor(es): dc.creatorHebling, Josimeri-
Autor(es): dc.creatorBriso, André Luiz Fraga-
Autor(es): dc.creatorde Souza Costa, Carlos Alberto-
Data de aceite: dc.date.accessioned2025-08-21T19:35:42Z-
Data de disponibilização: dc.date.available2025-08-21T19:35:42Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-022-04379-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230436-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230436-
Descrição: dc.descriptionObjectives: Evaluate in vitro the esthetic efficacy and cytotoxicity of a bleaching gel containing 35% hydrogen peroxide (BG-35%H2O2), applied for different time intervals, on enamel coated or not with polymeric biomaterials. Materials and methods: Nanofiber scaffolds (NSc) and a primer catalyst (PrCa) were used to coat the bovine enamel/dentin discs before the application of BG-35%H2O2, according to the following groups: G1—negative control (NC, without treatment); G2, G3, and G4—BG-35%H2O2 applied for 3 × 15, 2 × 15, and 15 min; G5, G6, and G7—BG-35%H2O2 applied on enamel coated with NSc and PrCa for 3 × 15; 2 × 15, and 15 min, respectively. The culture medium with components of gel diffused through the discs was applied on MDPC-23 cells, which were evaluated regarding to viability (VB), integrity of the membrane (IM), and oxidative stress (OxS). The quantity of H2O2 diffused and esthetic efficacy (ΔE/ΔWI) of the dental tissues were also analyzed (ANOVA/Tukey; p < 0.05). Results: Only G7 was similar to G1 regarding VB (p > 0.05). The lowest value of H2O2 diffusion occurred in G4 and G7, where the cells exhibited the lowest OxS than G2 (p < 0.05). Despite G5 showing the greatest ΔE regarding other groups (p < 0.05), the esthetic efficacy observed in G7 was similar to G2 (p > 0.05). ΔWI indicated a greater bleaching effect for groups G5, G6, and G7 (p < 0.05). Conclusion: Coating the dental enamel with polymeric biomaterials reduced the time and the cytotoxicity of BG-35%H2O2. Clinical significance. Coating the dental enamel with polymeric biomaterials allows safer and faster BG-35%H2O2 application.-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araraquara School of Dentistry São Paulo State University (Unesp), Rua Humaitá, 1680, SP-
Descrição: dc.descriptionDepartment of Operative Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo, Rua Alameda Dr. Octávio Pinheiro Brisolla, 9-75, SP-
Descrição: dc.descriptionDepartament of Orthodontics and Pediatric Dentistry Araraquara School of Dentistry University São Paulo State (Unesp), Rua Humaitá, 1680, SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Araçatuba School of Dentistry University São Paulo State University (Unesp), Rua José Bonifácio 1193-
Descrição: dc.descriptionDepartment of Physiology and Pathology Araraquara School of Dentistry São Paulo State University (Unesp), Rua Humaitá, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araraquara School of Dentistry São Paulo State University (Unesp), Rua Humaitá, 1680, SP-
Descrição: dc.descriptionDepartament of Orthodontics and Pediatric Dentistry Araraquara School of Dentistry University São Paulo State (Unesp), Rua Humaitá, 1680, SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Araçatuba School of Dentistry University São Paulo State University (Unesp), Rua José Bonifácio 1193-
Descrição: dc.descriptionDepartment of Physiology and Pathology Araraquara School of Dentistry São Paulo State University (Unesp), Rua Humaitá, SP-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectDental bleaching-
Palavras-chave: dc.subjectOdontoblasts-
Palavras-chave: dc.subjectPolymeric biomaterials-
Título: dc.titleStrategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching-
Tipo de arquivo: dc.typelivro digital-
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