Siolmatra brasiliensis stem extract ameliorates antioxidant defenses and mitigates glycoxidative stress in mice with high-fat diet-induced obesity

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstitute of Exact Sciences-
Autor(es): dc.creatorTalpo, Tassiana Cristina-
Autor(es): dc.creatorMotta, Bruno Pereira-
Autor(es): dc.creatorOliveira, Juliana Oriel de-
Autor(es): dc.creatorFigueiredo, Ingrid Delbone-
Autor(es): dc.creatorPinheiro, Camila Graça-
Autor(es): dc.creatordos Santos, Carlos Henrique Corrêa-
Autor(es): dc.creatorCarvalho, Mário Geraldo de-
Autor(es): dc.creatorBrunetti, Iguatemy Lourenço-
Autor(es): dc.creatorBaviera, Amanda Martins-
Data de aceite: dc.date.accessioned2025-08-21T20:40:36Z-
Data de disponibilização: dc.date.available2025-08-21T20:40:36Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.orcp.2022.02.004-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230398-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230398-
Descrição: dc.descriptionBackground: Obesity is accompanied by insulin resistance and glucose intolerance, which favor the onset of complications related to oxidative stress. The aim of this study was to investigate the effects and underlying mechanisms of hydroethanolic extract from Siolmatra brasiliensis stems on insulin resistance, glucose intolerance, advanced glycation end product (AGE) formation, and oxidative stress in mice with induced obesity. Methods: C57BL-6 J mice were fed a high-fat diet for 14 weeks and treated with 125 or 250 mg/kg S. brasiliensis extract during the last 7 weeks. The study assessed glucose tolerance and insulin sensitivity, lipid profile, plasma levels of thiobarbituric acid reactive substances (TBARS, biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 (PON1) activity (antioxidant enzyme). The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver and kidneys were also investigated. Results: Siolmatra brasiliensis extract had antiobesogenic effects; improved insulin sensitivity and glucose tolerance; decreased the total plasma cholesterol levels; decreased the levels of glycoxidative stress biomarkers, including AGEs (plasma, liver, kidneys) and TBARS (liver, kidneys); and also improved endogenous antioxidant defenses by increasing the activities of PON1 (plasma), SOD (kidneys), CAT (liver, kidneys), and GSH-Px (kidneys). Conclusion: This study expands on our knowledge about the pharmacological properties of S. brasiliensis and substantiates the potential of this plant species to be used as a complementary therapeutic agent to alleviate the metabolic dysfunctions resulting from dyslipidemia and glycoxidative stress.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Pharmaceutical Sciences Department of Clinical Analysis, São Paulo-
Descrição: dc.descriptionFederal Rural University of Rio de Janeiro (UFRRJ) Institute of Exact Sciences Department of Chemistry, Seropédica-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Pharmaceutical Sciences Department of Clinical Analysis, São Paulo-
Descrição: dc.descriptionCNPq: 147145/2018-0-
Descrição: dc.descriptionCNPq: 152992/2019-7-
Descrição: dc.descriptionCNPq: 305936/2017-4-
Descrição: dc.descriptionFAPESP: 98/09152-6-
Idioma: dc.languageen-
Relação: dc.relationObesity Research and Clinical Practice-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdvanced glycation end products-
Palavras-chave: dc.subjectAntioxidant defenses-
Palavras-chave: dc.subjectCucurbitaceae-
Palavras-chave: dc.subjectLipid peroxidation-
Palavras-chave: dc.subjectObesity-
Título: dc.titleSiolmatra brasiliensis stem extract ameliorates antioxidant defenses and mitigates glycoxidative stress in mice with high-fat diet-induced obesity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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