Use of remdesivir in patients with COVID-19: a systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAssociação Médica Brasileira-
Autor(es): dc.contributorCooperativa Baixa Mogiana-
Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorTanni, Suzana E.-
Autor(es): dc.creatorSilvinato, Antonio-
Autor(es): dc.creatorFloriano, Idevaldo-
Autor(es): dc.creatorBacha, Hélio A-
Autor(es): dc.creatorBarbosa, Alexandre Naime-
Autor(es): dc.creatorBernardo, Wanderley M.-
Data de aceite: dc.date.accessioned2025-08-21T22:27:04Z-
Data de disponibilização: dc.date.available2025-08-21T22:27:04Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.36416/1806-3756/e20210393-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230356-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230356-
Descrição: dc.descriptionOBJECTIVE: Studies in the literature regarding the use of remdesivir to treat COVID-19 patients have shown conflicting results. This study sought to answer questions related to the use of remdesivir for the treatment of patients hospitalized with moderate to severe COVID-19. METHODS: This was a systematic review and meta-analysis including phase 3 randomized clinical trials (RCTs) and observational cohort studies selected from various databases, comparing patients hospitalized with moderate to severe COVID-19 receiving remdesivir and controls. RESULTS: A total of 207 studies were retrieved, 9 of which met the eligibility criteria and were included in the study. The meta-analysis using RCTs alone showed no statistically significant differences regarding mortality or use of mechanical ventilation/extracorporeal membrane oxygenation between remdesivir and control groups, and the quality of evidence was moderate and low, respectively. The use of remdesivir increased the recovery rate by 6% (95% CI, 3-9); p = 0.004) and the clinical improvement rate by 7% (95% CI, 1-14); p = 0.02). Additionally, no significant differences in mortality were found between remdesivir and control groups when the meta-analysis used observational cohort studies alone (risk difference = -0.01 (95% CI, -0.02 to 0.01; p = 0.32), the quality of evidence being moderate, and the risk of adverse events was 4% ([95% CI, -0.08 to 0.01]; p = 0.09). CONCLUSIONS: The use of remdesivir for the treatment of patients with moderate to severe COVID-19 had no significant impact on clinically important outcomes.-
Descrição: dc.descriptionDisciplina de Pneumologia Departamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista - UNESP - Botucatu (SP) Brasil-
Descrição: dc.descriptionAssociação Médica Brasileira-
Descrição: dc.descriptionCooperativa Baixa Mogiana-
Descrição: dc.descriptionHospital Israelita Albert Einstein-
Descrição: dc.descriptionDepartamento de Infectologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista - UNESP - Botucatu (SP) Brasil-
Descrição: dc.descriptionFaculdade de Medicina Universidade de São Paulo-
Descrição: dc.descriptionDisciplina de Pneumologia Departamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista - UNESP - Botucatu (SP) Brasil-
Descrição: dc.descriptionDepartamento de Infectologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista - UNESP - Botucatu (SP) Brasil-
Formato: dc.formate20210393-
Idioma: dc.languageen-
Idioma: dc.languagept_BR-
Relação: dc.relationJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia-
???dc.source???: dc.sourceScopus-
Título: dc.titleUse of remdesivir in patients with COVID-19: a systematic review and meta-analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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