The Dermatophyte Trichophyton rubrum Induces Neutrophil Extracellular Traps Release by Human Neutrophils

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorInstituto Adolfo Lutz-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFiocruz Amazônia-
Autor(es): dc.creatorReis, Ana Paula Carvalho-
Autor(es): dc.creatorCelestrino, Giovanna Azevedo-
Autor(es): dc.creatorIgoa, Mariana Villas Bôas-
Autor(es): dc.creatorJesus, Thais Martins-
Autor(es): dc.creatorFrança, Tábata Takahashi-
Autor(es): dc.creatorMoreira, Daniel Valério Silva-
Autor(es): dc.creatorRigato, Paula Ordonhez-
Autor(es): dc.creatorSato, Paula Keiko-
Autor(es): dc.creatorCondino-Neto, Antonio-
Autor(es): dc.creatorNoronha, Irene L.-
Autor(es): dc.creatorDias-Melicio, Luciane Alarcão-
Autor(es): dc.creatorLalwani, Pritesh Jaychand-
Autor(es): dc.creatorBenard, Gil-
Autor(es): dc.creatorSousa, Maria Gloria Teixeira-
Data de aceite: dc.date.accessioned2025-08-21T22:11:16Z-
Data de disponibilização: dc.date.available2025-08-21T22:11:16Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof8020147-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230307-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230307-
Descrição: dc.descriptionNeutrophils are the first leukocytes recruited to the site of infection and are thought to be responsible for fungal elimination from the skin such as dermatophytes. Neutrophils are able to secrete reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) that can kill different fungi, including Aspergillus, spp., Candida albicans, and Phialophora verrucosa. However, NET production in response to Trichophyton rubrum, the main etiologic agent of dermatophytosis, has yet to be studied. We demonstrated that human neutrophils produce NETs against different morphotypes of T. rubrum in a dose-dependent manner and NET formation is dependent on ROS production. In addition, ROS production by human neutrophils in response to T. rubrum is dependent on NADPH oxidase, but not on fungal viability. NETs mediated killing of T. rubrum. Collectively, these results demonstrate that T. rubrum was able to trigger the production of NETs, suggesting that these extracellular structures may represent an important innate immune effector mechanism controlling physiological response to T. rubrum infection.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Medical Mycology LIM-53 Clinical Dermatology Division Hospital das Clínicas FMUSP Faculdade de Medicina FMUSP Institute of Tropical Medicine University of São Paulo-
Descrição: dc.descriptionLaboratory of Cellular Genetic and Molecular Nephrology Division of Nephrology University of São Paulo School of Medicine-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionCentro de Imunologia Instituto Adolfo Lutz-
Descrição: dc.descriptionLaboratory of Medical Investigation in Immunology (LIM-48) Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School UNESP-São Paulo State University-
Descrição: dc.descriptionLeonidas e Maria Deane Institute Fiocruz Amazônia-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School UNESP-São Paulo State University-
Descrição: dc.descriptionFAPESP: 2016/16369-1-
Descrição: dc.descriptionFAPESP: 2017/26208-8-
Descrição: dc.descriptionFAPESP: 2018/16146-8-
Descrição: dc.descriptionFAPESP: 2018/19191-2-
Descrição: dc.descriptionFAPESP: 2018/24175-8-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDermatophytosis-
Palavras-chave: dc.subjectFungal killing-
Palavras-chave: dc.subjectInnate immunity-
Palavras-chave: dc.subjectNeutrophil extracellular traps-
Palavras-chave: dc.subjectNeutrophils-
Palavras-chave: dc.subjectTrichophyton rubrum-
Título: dc.titleThe Dermatophyte Trichophyton rubrum Induces Neutrophil Extracellular Traps Release by Human Neutrophils-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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