Study of antimycobacterial, cytotoxic, and mutagenic potential of polymeric nanoparticles of copper (II) complex

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Autor(es): dc.contributorUniversity of Araraquara (UNIARA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorUniversidad Nacional de La Plata–CONICET (CCT La Plata)-
Autor(es): dc.contributorCentro de Estudios Interdisciplinarios (CEI)-
Autor(es): dc.contributorINTEC-
Autor(es): dc.creatorAleixo, Nadia Andrade-
Autor(es): dc.creatorGomes, Pietra Stefany da Silva-
Autor(es): dc.creatorSilva, Patrícia Bento da-
Autor(es): dc.creatorSato, Mariana Rillo-
Autor(es): dc.creatorCampos, Débora Leite-
Autor(es): dc.creatorBarud, Hernane da Silva-
Autor(es): dc.creatorCastro, Guillermo Raul-
Autor(es): dc.creatorIslan, German Abel-
Autor(es): dc.creatorToledo, Constanza-
Autor(es): dc.creatorKarp, Federico-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorResende, Flávia Aparecida-
Data de aceite: dc.date.accessioned2025-08-21T19:11:38Z-
Data de disponibilização: dc.date.available2025-08-21T19:11:38Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/02652048.2022.2025935-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230267-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230267-
Descrição: dc.descriptionThis study aimed to encapsulate and characterise a potential anti-tuberculosis copper complex (CuCl2(INH)2.H2O:I1) into polymeric nanoparticles (PNs) of polymethacrylate copolymers (Eudragit®, Eu) developed by nanoprecipitation method. NE30D, S100 and, E100 polymers were tested. The physicochemical characterisations were performed by DLS, TEM, FTIR, encapsulation efficiency and, in vitro release studies. Encapsulation of I1 in PN-NE30D, PN-E100, and PN-S100 was 26.3%, 94.5%, 22.6%, respectively. The particle size and zeta potentials were 82.3 nm and −24.5 mV for PNs-NE30D, 304.4 nm and +18.7 mV for PNs-E100, and 517.9 nm and −6.9 mV for PNs-S100, respectively. All PDIs were under 0.5. The formulations showed an I1 controlled release at alkaline pH with 29.7% from PNs-NE30D, 7.9% from PNs-E100 and, 28.1% from PNs-S100 at 1 h incubation. PNs were stable for at least 3 months. Particularly, PNs-NE30D demonstrated moderate inhibition of M. tuberculosis and low cytotoxic activity. None of the PNs induced mutagenicity.-
Descrição: dc.descriptionDepartment of Biological Sciences and Health University of Araraquara (UNIARA)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionNanobiotechnology Laboratory Institute of Biological Sciences Department of Genetics and Morphology University of Brasilia-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFacultad de Ciencias Exactas Departmento de Química CINDEFI Laboratorio de Nanobiomateriales Universidad Nacional de La Plata–CONICET (CCT La Plata)-
Descrição: dc.descriptionMax Planck Laboratory for Structural Biology Chemistry and Molecular Biophysics of Rosario (MPLbioR UNR-MPIbpC) Partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC MPG) Universidad Nacional de Rosario Centro de Estudios Interdisciplinarios (CEI)-
Descrição: dc.descriptionLaboratorio de Química Fina (UNL-CONICET) Universidad Nacional del Litoral (UNL) INTEC-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format61-71-
Idioma: dc.languageen-
Relação: dc.relationJournal of Microencapsulation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCopper(II) complexes-
Palavras-chave: dc.subjectEudragit®-
Palavras-chave: dc.subjectmutagenicity-
Palavras-chave: dc.subjectpolymeric matrices-
Palavras-chave: dc.subjectresazurin assay-
Título: dc.titleStudy of antimycobacterial, cytotoxic, and mutagenic potential of polymeric nanoparticles of copper (II) complex-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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