Use of hyaluronic acid associated with triamcinolone acetonide or ozone gas in the treatment of induced osteoarthritis in rabbits

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorBioethicus Institute-
Autor(es): dc.contributorPrivate Practice-
Autor(es): dc.creatorBrombini, Giovanna Cristina-
Autor(es): dc.creatorRahal, Sheila Canevese-
Autor(es): dc.creatorFabro, Alexandre Todorovic-
Autor(es): dc.creatorDos Santos, Ivan Felismino Charas-
Autor(es): dc.creatorTsunemi, Miriam Harumi-
Autor(es): dc.creatorJoaquim, Jean Guilherme Fernandes-
Autor(es): dc.creatorDoiche, Danuta Pulz-
Autor(es): dc.creatorDa Silva, Jeana Pereira-
Autor(es): dc.creatorMamprim, Maria Jaqueline-
Data de aceite: dc.date.accessioned2025-08-21T18:11:26Z-
Data de disponibilização: dc.date.available2025-08-21T18:11:26Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/ACB361201-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230242-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230242-
Descrição: dc.descriptionPurpose: To evaluate the effects of the intra-articular application of hyaluronic acid associated with triamcinolone acetonide, and ozone gas in the treatment of induced osteoarthritis in rabbit’s stifles. Methods: Twenty-one Norfolk rabbits were submitted to cranial cruciate ligament transection of the left stifle. After six weeks of the surgery, the rabbits were randomized assigned into three groups: G1 (control) – saline solution (0.9%); G2 – hyaluronic acid associated with triamcinolone; G3 – ozone gas, submitted to three intra-articular applications every seven days. Results: Significant differences occurred: Osteophytes at medial femoral condyle (G2 > G1, G2 > G3) on radiography exam; thickening of the medial condyle (G1 > G3, G2 > G3) on ultrasound exam; osteophytes at lateral tibial condyle (G2 > G1, G2 > G3), and medial femoral condyle (G1 > G2, G3 > G1) on computed tomography. Histologically, mean values of chondrocytes in the femur and tibia in G3 and G2 were statistically lower. Conclusion: The intra-articular injection of hyaluronic acid associated with triamcinolone accentuated degenerative joint disease by imaging and macroscopic evaluations, and by histological findings, this treatment and the ozone gas treatment showed similar effects and were inferior to the saline solution (0.9%).-
Descrição: dc.descriptionPostgraduate Program in Animal Biotechnology School of Veterinary Medicine and Animal Science (FMVZ) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction (FMVZ) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Universidade de São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences of Botucatu (IBB) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionBioethicus Institute, SP-
Descrição: dc.descriptionPrivate Practice, SP-
Descrição: dc.descriptionPostgraduate Program in Wild Animals Department of Veterinary Surgery and Animal Reproduction (FMVZ) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionPostgraduate Program in Animal Biotechnology School of Veterinary Medicine and Animal Science (FMVZ) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction (FMVZ) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Biostatistics Institute of Biosciences of Botucatu (IBB) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionPostgraduate Program in Wild Animals Department of Veterinary Surgery and Animal Reproduction (FMVZ) Universidade Estadual Paulista (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdrenal Cortex Hormones-
Palavras-chave: dc.subjectOzone-
Palavras-chave: dc.subjectPolysaccharides-
Palavras-chave: dc.subjectRabbits-
Título: dc.titleUse of hyaluronic acid associated with triamcinolone acetonide or ozone gas in the treatment of induced osteoarthritis in rabbits-
Tipo de arquivo: dc.typelivro digital-
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