P-Glycoprotein and Androgen Receptor Expression Reveals Independence of Canine Prostate Cancer from Androgen Hormone Stimulation

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Goias—UFG-
Autor(es): dc.contributorPaulista University—UNIP-
Autor(es): dc.creatorCavalca, Alexandre Matheus Baesso-
Autor(es): dc.creatorBrandi, Andressa-
Autor(es): dc.creatorFonseca-Alves, Ricardo Henrique-
Autor(es): dc.creatorLaufer-Amorim, Renée-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T21:01:09Z-
Data de disponibilização: dc.date.available2025-08-21T21:01:09Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms23031163-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230240-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230240-
Descrição: dc.descriptionCanine prostate cancer (PC) is an aggressive disease, and dogs can be considered comparative models for human PC. In recent years, canine PC has been shown to resemble human castrate-resistant prostate cancer. The influx and efflux of testosterone in prostatic luminal cells are regulated by P-glycoprotein (P-gp). Therefore, human PC generally lacks P-gp expression and maintains the expression of androgen receptors (ARs). However, this co-expression has not previ-ously been investigated in dogs. Therefore, this study aimed to evaluate AR and P-gp co-expression to elucidate these protein patterns in canine prostate samples. We identified AR/P-gp double im-munofluorescence co-expression of both proteins in normal luminal cells. However, in canine PC, cells lack AR expression and exhibit increased P-gp expression. These results were confirmed by gene expression analyses. Overall, our results strongly suggest that normal canine prostate testosterone influx may be regulated by P-gp expression, and that during progression to PC, prostatic cells lack AR expression and P-gp overexpress. P-gp expression in canine PC may be related to a phenotype of multiple drug resistance.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionDepartment of Electrical Engineering School of Electrical Mechanical and Computer Engineering Federal University of Goias—UFG-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionInstitute of Health Sciences Paulista University—UNIP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University—UNESP-
Descrição: dc.descriptionFAPESP: 2015/25400-7-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectABCB1-
Palavras-chave: dc.subjectComparative oncology-
Palavras-chave: dc.subjectProstatic disease-
Palavras-chave: dc.subjectTestosterone-
Título: dc.titleP-Glycoprotein and Androgen Receptor Expression Reveals Independence of Canine Prostate Cancer from Androgen Hormone Stimulation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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