Modified zinc oxide nanoparticles against multiresistant Enterobacteriaceae: stability, growth studies, and antibacterial activity

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributor351-
Autor(es): dc.contributorUNIFACISA Centro Universitário-
Autor(es): dc.contributorCNRS-
Autor(es): dc.creatorLallo da Silva, Bruna-
Autor(es): dc.creatorGarcia, Mariana Marin-
Autor(es): dc.creatorOshiro-Junior, João Augusto-
Autor(es): dc.creatorSato, Mariana Rillo-
Autor(es): dc.creatorCaetano, Bruno Leonardo-
Autor(es): dc.creatorChiavacci, Leila Aparecida-
Data de aceite: dc.date.accessioned2025-08-21T16:56:56Z-
Data de disponibilização: dc.date.available2025-08-21T16:56:56Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10971-021-05681-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230200-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230200-
Descrição: dc.descriptionThe development of new strategies to combat bacterial growth is a focus of many studies. Zinc oxide nanoparticles (ZnO NP) have been shown to possess great antibacterial activity. ZnO NP antibacterial activity is highly dependent on particle size, with smaller sized NP achieving higher performance. Based on this property, in the current study, we have demonstrated the formation and growth of small ZnO NP with 5 nm synthesized by a sol–gel method and characterized by small-angle X-ray scattering (SAXS). The radius of the ZnO NP increased throughout the synthesis, being more pronounced in the beginning of the synthesis (10–20 min) and continuing to grow more slowly until 180 min. The surface of the ZnO NP was modified by (3-glycidyloxypropyl) trimethoxysilane (GPTMS) dispersed in water without significant changes to the ZnO NP size. GPTMS-ZnO NP stability studies realized by zeta potential, SAXS, and UV–vis spectroscopy demonstrated that GPTMS-ZnO NP dispersed in water were stable for 62 days when stored at 5 °C and for 35 days when stored at room temperature, with no size increase detected. ZnO NP dissolve in acidic pH, are stable at alkaline pH, and form fractal aggregates at pH 7. The GPTMS-ZnO NP antibacterial activity against ESBL-producing Escherichia coli and carbapenemase (KPC)-producing Klebsiella pneumoniae was assessed. The GPTMS-ZnO NP had excellent antibacterial activity. To date, there are no studies on GPTMS-ZnO NP antibacterial activity against multiresistant Enterobacteriaceae. Thus, this study indicates that GPTMS-ZnO NP have great potential to combat multiresistant enterobacteria.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Drugs and Medicines Highway Araraquara-Jaú São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduation Program in Pharmaceutical Sciences State University of Paraíba Av. Baraúnas 351, PB-
Descrição: dc.descriptionUNIFACISA Centro Universitário, PB-
Descrição: dc.descriptionSoft Matter Sciences and Engineering ESPCI Paris PSL University Sorbonne Université CNRS-
Descrição: dc.descriptionPhysico-chimie des Electrolytes et Nanosystèmes Interfaciaux PHENIX Sorbonne Université CNRS-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Department of Drugs and Medicines Highway Araraquara-Jaú São Paulo State University (UNESP), SP-
Formato: dc.format244-255-
Idioma: dc.languageen-
Relação: dc.relationJournal of Sol-Gel Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBacterial resistance-
Palavras-chave: dc.subjectSize-
Palavras-chave: dc.subjectStability-
Palavras-chave: dc.subjectSurface modifier-
Palavras-chave: dc.subjectZinc oxide nanoparticles-
Título: dc.titleModified zinc oxide nanoparticles against multiresistant Enterobacteriaceae: stability, growth studies, and antibacterial activity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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