Nebulized enriched heparin to treat no critical patients with Sars-Cov-2 Triple-blind clinical trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorKeele University-
Autor(es): dc.contributorCellavita Scientific Research-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorBertanha, Matheus-
Autor(es): dc.creatorda Silva Rodrigues, Lenize-
Autor(es): dc.creatorMellucci Filho, Pedro Luciano-
Autor(es): dc.creatorMoroz, Andrei-
Autor(es): dc.creatorde Moura Campos Pardini, Maria Inês-
Autor(es): dc.creatorSobreira, Marcone Lima-
Autor(es): dc.creatorDurigon, Edison Luiz-
Autor(es): dc.creatorGuaragna Machado, Rafael Rahal-
Autor(es): dc.creatorTommasini Grotto, Rejane Maria-
Autor(es): dc.creatorde Lima, Marcelo Andrade-
Autor(es): dc.creatorNader, Helena Bonciani-
Autor(es): dc.creatorde Moraes, Marli Leite-
Autor(es): dc.creatorBarbosa, Alexandre Naime-
Autor(es): dc.creatorMedolago, Natália Bronzatto-
Autor(es): dc.creatorCardoso, Fábio Florença-
Autor(es): dc.creatorMagro, Angelo José-
Autor(es): dc.creatorGuzzo Carvalho, Cristiane Rodrigues-
Autor(es): dc.creatorde Moraes, Leonardo Nazário-
Autor(es): dc.creatorde Cássia Alvarado, Rita-
Autor(es): dc.creatorNunes, Helga Caputo-
Autor(es): dc.creatorde Campos, Gustavo Constantino-
Autor(es): dc.creatorda Silva Grillo, Vinicius Tadeu Ramos-
Autor(es): dc.creatorSertorio, Nathalia Dias-
Autor(es): dc.creatorBranco Fortaleza, Carlos Magno Castelo-
Data de aceite: dc.date.accessioned2025-08-21T15:45:08Z-
Data de disponibilização: dc.date.available2025-08-21T15:45:08Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/MD.0000000000028288-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230182-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230182-
Descrição: dc.descriptionBackground: Coronavirus disease 2019 (COVID-19) is a viral respiratory disease that spreads rapidly, reaching pandemic status, causing the collapse of numerous health systems, and a strong economic and social impact. The treatment so far has not been well established and there are several clinical trials testing known drugs that have antiviral activity, due to the urgency that the global situation imposes. Drugs with specific mechanisms of action can take years to be discovered, while vaccines may also take a long time to be widely distributed while new virus variants emerge. Thus, drug repositioning has been shown to be a good strategy for defining new therapeutic approaches. Studies of the effect of enriched heparin in the replication of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) in vitro assays justify the advance for clinical tests. Methods and analysis: A phase I/II triple-blind parallel clinical trial will be conducted. Fifty participants with radiological diagnosis of grade IIA pneumonia will be selected, which will be allocated in 2 arms. Participants allocated in Group 1 (placebo) will receive nebulized 0.9% saline. Participants allocated in Group 2 (intervention) will receive nebulized enriched heparin (2.5 mg/mL 0.9% saline). Both groups will receive the respective solutions on a 4/4 hour basis, for 7 days. The main outcomes of interest will be safety (absence of serious adverse events) and efficacy (measured by the viral load). Protocols will be filled on a daily basis, ranging from day 0 (diagnosis) until day 8.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionApplied Biotechnology Laboratory Research Nucleus of Clinical Hospital São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology São Paulo State University – UNESP School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionInternal Medicine Division São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biomedical Sciences University of São Paulo – USP, SP-
Descrição: dc.descriptionScientific Platform Pasteur University of São Paulo – USP, SP-
Descrição: dc.descriptionBioprocessing and Biotechnology Department São Paulo State University – UNESP School of Agriculture, SP-
Descrição: dc.descriptionMolecular & Structural Biosciences School of Life Sciences Keele University, Newcastle-Under-Lyme-
Descrição: dc.descriptionDepartment of Biochemistry Federal University of São Paulo – UNIFESP, SP-
Descrição: dc.descriptionInstitute of Science and Technology Federal University of São Paulo – UNIFESP, SP-
Descrição: dc.descriptionDepartment of Infectious Diseases São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionClinical Research Unit São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionBiosciences Institute São Paulo State University UNESP, SP-
Descrição: dc.descriptionQuality Control Laboratory Cellavita Scientific Research, SP-
Descrição: dc.descriptionDepartment of Orthopedics and Traumatology University of Campinas – UNICAMP School of Medical Sciences, SP-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionApplied Biotechnology Laboratory Research Nucleus of Clinical Hospital São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology São Paulo State University – UNESP School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionInternal Medicine Division São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionBioprocessing and Biotechnology Department São Paulo State University – UNESP School of Agriculture, SP-
Descrição: dc.descriptionDepartment of Infectious Diseases São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionClinical Research Unit São Paulo State University – UNESP Botucatu Medical School, SP-
Descrição: dc.descriptionBiosciences Institute São Paulo State University UNESP, SP-
Descrição: dc.descriptionFAPESP: 2020/12165-8-
Formato: dc.formatE28288-
Idioma: dc.languageen-
Relação: dc.relationMedicine (United States)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiviral agents-
Palavras-chave: dc.subjectClinical protocol-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectHeparin-
Palavras-chave: dc.subjectInhalation-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleNebulized enriched heparin to treat no critical patients with Sars-Cov-2 Triple-blind clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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