Potential of Fibrin Glue and Mesenchymal Stem Cells (MSCs) to Regenerate Nerve Injuries: A Systematic Review

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversity Center of Adamantina (UniFAI)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorJundiaí Medical School-
Autor(es): dc.creatorOrtiz, Adriana de Cássia-
Autor(es): dc.creatorFideles, Simone Ortiz Moura-
Autor(es): dc.creatorPomini, Karina Torres-
Autor(es): dc.creatorBellini, Márcia Zilioli-
Autor(es): dc.creatorPereira, Eliana de Souza Bastos Mazuqueli-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorPilon, João Paulo Galletti-
Autor(es): dc.creatorde Marchi, Miguel Ângelo-
Autor(es): dc.creatorTrazzi, Beatriz Flavia de Moraes-
Autor(es): dc.creatorda Silva, Willian Saranholi-
Autor(es): dc.creatorda Cunha, Marcelo Rodrigues-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Data de aceite: dc.date.accessioned2025-08-21T19:11:10Z-
Data de disponibilização: dc.date.available2025-08-21T19:11:10Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells11020221-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230173-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230173-
Descrição: dc.descriptionCell-based therapy is a promising treatment to favor tissue healing through less invasive strategies. Mesenchymal stem cells (MSCs) highlighted as potential candidates due to their angio-genic, anti-apoptotic and immunomodulatory properties, in addition to their ability to differentiate into several specialized cell lines. Cells can be carried through a biological delivery system, such as fibrin glue, which acts as a temporary matrix that favors cell-matrix interactions and allows local and paracrine functions of MSCs. Thus, the aim of this systematic review was to evaluate the potential of fibrin glue combined with MSCs in nerve regeneration. The bibliographic search was performed in the PubMed/MEDLINE, Web of Science and Embase databases, using the descriptors (“fibrin sealant” OR “fibrin glue”) AND “stem cells” AND “nerve regeneration”, considering articles published until 2021. To compose this review, 13 in vivo studies were selected, according to the eligibility criteria. MSCs favored axonal regeneration, remyelination of nerve fibers, as well as promoted an increase in the number of myelinated fibers, myelin sheath thickness, number of axons and expression of growth factors, with significant improvement in motor function recovery. This systematic review showed clear evidence that fibrin glue combined with MSCs has the potential to regenerate nervous system lesions.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)-
Descrição: dc.descriptionPro-Rectory of Research and Graduate Studies University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) Medical School University of Marilia (UNIMAR)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)-
Descrição: dc.descriptionCoordination of the Medical School University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionCoordination of the Dentistry School University of Marilia (UNIMAR)-
Descrição: dc.descriptionDentistry School University of Marilia (UNIMAR)-
Descrição: dc.descriptionInterunit Postgraduate Program in Bioengineering (EESC/FMRP/IQSC) University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Morphology and Pathology Jundiaí Medical School-
Descrição: dc.descriptionTeaching and Research Coordination of the Medical School University Center of Adamantina (UniFAI)-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Univ Estadual Paulista)-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFibrin glue-
Palavras-chave: dc.subjectFibrin sealant-
Palavras-chave: dc.subjectNerve regeneration-
Palavras-chave: dc.subjectScaffolds-
Palavras-chave: dc.subjectStem cells-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titlePotential of Fibrin Glue and Mesenchymal Stem Cells (MSCs) to Regenerate Nerve Injuries: A Systematic Review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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