Mucoadhesive controlled-release formulations containing morin for the control of oral biofilms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Araraquara–UNIARA-
Autor(es): dc.creatorde Farias, Aline Leite-
Autor(es): dc.creatorArbeláez, Maria Isabel Amaya-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorBarud, Hernane da Silva-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção-
Data de aceite: dc.date.accessioned2025-08-21T16:49:57Z-
Data de disponibilização: dc.date.available2025-08-21T16:49:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/08927014.2021.2015580-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230095-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230095-
Descrição: dc.descriptionThis study aimed to evaluate the antimicrobial and anti-biofilm activity of morin on polymicrobial biofilms and its cytotoxicity in controlled-release films and tablets based on gellan gum. Polymicrobial biofilms were formed from saliva for 48 h under an intermittent exposure regime to 1% sucrose and in contact with films or tablets of gellan gum containing 2 mg of morin each. Acidogenicity, bacterial viability, dry weight and insoluble extracellular polysaccharides from biofilms were evaluated. The cytotoxicity of morin was evaluated in oral keratinocytes. Morin released from the systems reduced the viability of all the microbial groups evaluated, as well as the dry weight and insoluble polysaccharide concentration in the matrix and promoted the control of acidogenicity when compared with the control group without the substance. Morin was cytotoxic only at the highest concentration evaluated. In conclusion, morin is an effective agent and shows antimicrobial and anti-biofilm activity against polymicrobial biofilms.-
Descrição: dc.descriptionDepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University–UNESP, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University–UNESP, SP-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University–UNESP, SP-
Descrição: dc.descriptionBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara–UNIARA, SP-
Descrição: dc.descriptionDepartment of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University–UNESP, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University–UNESP, SP-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University–UNESP, SP-
Formato: dc.format71-83-
Idioma: dc.languageen-
Relação: dc.relationBiofouling-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcontrolled drug release-
Palavras-chave: dc.subjectDental plaque-
Palavras-chave: dc.subjectfilm-
Palavras-chave: dc.subjectgellan gum-
Palavras-chave: dc.subjectpolymicrobial biofilm-
Palavras-chave: dc.subjecttablet-
Título: dc.titleMucoadhesive controlled-release formulations containing morin for the control of oral biofilms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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